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- 2. Nanoscale Technology Enables Complexity at Larger Scales……. Self-assembled cartilage Cells cultured in matrigel clusters Guided cell
- 3. Role of Scale (Size AND Organization) Nanopatterning and biofunctionalized surfaces Cell colonies and biomaterial clusters Single
- 4. Ingredient I, Biomimetics/ Biocompatibility Biomimetics: engineering design that mimics natural systems. Nature has evolved things better
- 5. Artificial Skin, Two Approaches Approximating cellular function: Approximating electrophysiology: “Nanowire active-matrix circuitry for low- voltage macroscale
- 6. Artificial Skin – Response Characteristics Results for stimulation of electronic skin: Output signal from electronic skin,
- 7. Silk as Substrate, Two Approaches Nanoconfinement M. Buehler, Nature Materials, 9, 359 (2010) Bio-integrated Electronics. J.
- 8. Ingredient II, Flexible Electronics Q: how do we incorporate the need for compliance in a device
- 9. E-skin for Applications Organic field effect transistors (OFETs): * use polymers with semiconducting properties. Thin-film Transistors
- 10. Ingredient III, Nanopatterning Q: how do we get cells in culture to form complex geometries? PNAS
- 11. MWCNTs as Substrate for Neurons Multi-Wall CNT substrate for HC neurons: Nano Letters, 5(6), 1107-1110 (2005).
- 12. Bottom-up vs. Top-down Approaches Soft Matter, 5, 1312–1319 (2009). Theoretically, there are two basic approaches to
- 13. Top-down approach: Electrospinning Right: Applied Physics Letters, 82, 973 (2003). Left: “Nanotechnology and Tissue Engineering: the
- 14. Bottom-up approach: Molecular Self-assembly Protein and peptide approaches commonly used. Protein approach – see review, Progress
- 15. Additional Tools: Memristor Memristor: information-processing device (memory + resistor, Si-based) at nanoscale. * conductance incrementally modified
- 16. Additional Tools: Bioprinting Bioprinting: inkjet printers can deposit layers on a substrate in patterned fashion. *
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