Содержание
- 2. Computational biology Computational biology is an interdisciplinary field that applies the techniques of computer science, applied
- 3. It encompasses the fields of : Computational biomodeling, a field concerned with building computer models of
- 4. Mathematical biology aims at the mathematical representation, treatment and modeling of biological processes, using a variety
- 5. Molecular modeling, which consists of modelling the behaviour of molecules of biological importance. Protein structure prediction
- 6. IUPS Physiome Project
- 7. IUPS Physiome Project The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting
- 8. IUPS Physiome Project
- 9. Physiome Bioinformatics Genes Proteins Biophysical models Constitutive laws Organ model Whole body model Genome Protein Physiology
- 10. Mathematical Models Level 1 models: Molecular models Level 2 models: Subcellular Markov models Level 3 models:
- 11. Visualization Tools Interrogation of model parameters Animated visualization of computational output From molecular level through to
- 12. Instrumentation Structural measurements geometry and tissue microstructure of organs present methods too slow and tedious Material
- 13. Physiome Groups BioNoME (UCSD) Biology Network of Modeling Efforts; Cardiome Project the model and most active
- 14. IUPS Physiome Project.PhysioML
- 15. IUPS Physiome Project Spatial and temporal scales The wide range of spatial and temporal scales encompassed
- 16. IUPS Physiome Project
- 17. What is – ontology? Ontology - the "science of being" - typically has different meanings in
- 18. Several philosophers - from Aristoteles (4th Century BC) to Leibniz (1646-1716), and more recently the 19th
- 19. Sowa proposes the following: "The subject of ontology is the study of the categories of things
- 20. The use of ontologies in medicine is mainly focussed on the representation and (re-)organization of medical
- 21. Benefits Ontologies can help build more powerful and more interoperable information systems in healthcare. Ontologies can
- 22. IUPS Physiome Project Model ontologies All organ systems have now been defined. See www.bioeng.auckland.ac.nz/physiome/physiome.php). The web
- 23. Anatomy Completed or underway: Vent. geom. & fibre-sheet structure for dog Vent. geom. & fibre-sheets for
- 24. Mechanics Completed or underway: Material properties - biaxial tests on dog myocardium (AU) shear testing of
- 25. Activation Completed or underway: Ionic current models Spatial distribution of ion channels SA, atrial, AV, HIS,
- 26. IUPS Physiome Project AnatML This markup language is being developed to describe anatomy. AnatML files have
- 27. IUPS Physiome Project CellML This markup language is being developed to deal with models covering all
- 28. IUPS Physiome Project PhysioML The PhysioML markup language is being developed to describe systems level physiological
- 29. IUPS Physiome Project.PhysioML Computational models of organ systems Computational models of organ systems, such as the
- 30. IUPS Physiome Project.PhysioML Computational models of organ systems The process of integrating from cell (osteoclast) to
- 31. IUPS Physiome Project.PhysioML Cardiom Project
- 32. IUPS Physiome Project Relationship between the Physiome and other areas of biological organization
- 33. SBML SBML is a machine-readable format for representing models. It's oriented towards describing systems where biological
- 34. SBML Wrapper Contains One Model Model
- 35. How Is an SBML Document Structured? Model Compartment Reaction Species
- 36. ‘reactant’ Основные функциональные единицы SBML Компартаменты Вещества Реакции ‘modifier’ ‘product’ M M M M M M
- 37. Reactions According to SBML Reactants R Products P Modifiers M ‘Kinetic law’: v = f(R, P,
- 38. What Does SBML Look Like?
- 39. XML info
- 40. SBML Wrapper
- 41. Model
- 42. Compartment List
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