Rehabilitation

Содержание

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Cancer, cardiac disease, Amputations orthopedic injuries, arthritis, It is prescribed after

Cancer, cardiac disease,

Amputations
orthopedic injuries,
arthritis,

It is prescribed after many types

of injury, illness, or disease, including

spinal cord injuries,
stroke,
traumatic brain injurie
neurological problems,

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Definition Rehabilitation is a treatment or treatments designed to facilitate the

  Definition
Rehabilitation is a treatment or treatments designed
to facilitate the


process of recovery
from injury, illness, or disease to as normal condition as possible.
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GOALS Minimize functional deficits Use remaining function to maximum Prevent complications Minimize functional deficits Prevent complications

GOALS

Minimize functional deficits

Use remaining function to maximum

Prevent complications

Minimize functional deficits

Prevent complications

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*Developed and delivered by the rehabilitation Team . *Patient participation is

*Developed and delivered by the rehabilitation Team .
*Patient participation is essential

.
*Family understanding and commitment to the program .

Rehabilitation Program

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The key to Good Rehabilitation

The key to Good Rehabilitation

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Rehabilitation should be Comprehensive,with extended care program . Patient outcomes should include increased Independence .

Rehabilitation should be Comprehensive,with
extended care program .
Patient

outcomes should include increased Independence .
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What diagnostic tools are used in phy medical history, physical examinations,

What diagnostic tools are used in phy
medical history,
physical examinations,
X-rays.CT,MRI
.Electromyography

(EMG), nerve conduction studies.
Musculoskeletal ultrasound
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Physiatrists utilize Medications Injections. Physical modalities. Exercise. Education individualized to the patient`s needs. Assistive Devices

Physiatrists utilize
Medications
Injections.
Physical modalities.
Exercise.
Education individualized to the patient`s needs.
Assistive

Devices
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Physician specialists head Rehabilitation teams including a *The physical therapist *occupational

Physician specialists head Rehabilitation teams including a
*The physical therapist
*occupational therapist.
* The

social workers
Rehabilitation nurse,
psychological counselor
Speech&a respiratory therapist .
Rehabilitation engineer
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Definition of stroke *A cerebrovascular event with rapidly developing clinical signs

Definition of stroke
*A cerebrovascular event with rapidly developing clinical signs of

focal or global disturbances ,with no apparent cause other than of cerebral function with signs lasting 24 hours or longer or leading to death,with no apparent cause other than vascular origin(WHO).
symptoms less than 24 hours=TIA.
Transient ischemic attack
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*HEMORRHAGIC(15%) -interacerebral(hypertention) -subarachnoid(ruptured aneurysm) ISCHEMIC(85%) -thrombotic --embolic TYPES OF STROKE

*HEMORRHAGIC(15%) -interacerebral(hypertention) -subarachnoid(ruptured aneurysm)

ISCHEMIC(85%) -thrombotic --embolic

TYPES OF STROKE

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The physical therapist The physical therapist assists the patient in functional

The physical therapist

The physical therapist assists the patient in functional restoration.
Tasks

may include the following
ROM.,Muscle Strength
,Sitting , Standing , Balance, Coordination ,Transfers, and Ambulation, Including wheelchair and Bipedal.
*Progressive Gait training.
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OCCUPATIONAL THERAPISTS Are responsible for those therapeutic activities associated with patient’s

OCCUPATIONAL THERAPISTS Are responsible for those therapeutic activities associated with patient’s

daily life, (ADL) from simple Household & Personal Activities to Work and Leisure.
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Occupational therapy This may be achieved by restoring old skills or

Occupational therapy
This may be achieved
by restoring old skills
or teaching

the patient new skills to adjust to disabilities through
adaptive equipment,
orthotics,&
modification of the patient's
home environment.
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The social workers Evaluation of the patient’s total Living Situation, Including

The social workers

Evaluation of the patient’s total Living Situation, Including
.

Lifestyle, Family,
Finances, and
Community resources
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Therapeutic Recreation implements various interventions as a form of treatment to

Therapeutic Recreation

implements various interventions
as a form of treatment
to increase

physical, cognitive, emotional and social abilities
which may have been altered due to personal trauma or disease.
sPORTS ACTIVITIES
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Hand Held Reacher Flexible Sock Aid Grip Drink Holder What Are

Hand Held Reacher

Flexible Sock Aid

Grip Drink Holder

What Are Assistive Devices

Assistive devices

can help a person function better and be more independent

Assistive devices can make daily tasks easier.
.

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Pediatric Walkers Types of Mobility Aids help with walking or moving

                                                       Pediatric

Walkers

Types of Mobility Aids

help with
walking or moving
from place

to place.

They can help
prevent falls
improve independence.

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Orthotist — A health care professional who is skilled in making

Orthotist — A health care professional who is skilled
in making

and fitting
orthopedic appliances.
Prosthetist — A health care professional who is skilled in making and fitting
artificial parts (prosthetics)
for the human body.
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Clinical evaluation

Clinical evaluation

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Neurologic recovery after a SCI Occurs over a period of 18

Neurologic recovery after a SCI
Occurs over a period of 18

months. The greatest amount of recovery occurs within the first 3 - 6 months.
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We Begin Our Work With the Spinal Cord Patient by :

We Begin Our Work With the Spinal Cord Patient by :

Early

on, the PT' works with the patient to Prevent the terrible Complications of immobility:
Contractures
Pressure sores
Drops in Blood Pressure
The build up of secretions in the lungs
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The Vocational rehabilitation program will assist in training and placing disabled

The Vocational rehabilitation program will assist in training and placing disabled

persons in new jobs.

Vocational Rehabilitation

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NECK PAIN لواء أد رضا عوض

NECK
PAIN

لواء
أد
رضا عوض

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Anatomy Head weighing 6:8 1b 7 cervical vertebrae 5 intervertebral discs

Anatomy

Head weighing 6:8 1b
7 cervical vertebrae
5 intervertebral discs
12 joints of Luschka
14

apophyseal joints.
System of ligaments
(ant. long, post. long ,lig. flavum , interspinous and ligamentum nuchae)
Muscles
(14 paired anterior lateral & post)
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Prevalence Neck Stiffness 25 : 30 % Age 25-29 year Up

Prevalence

Neck Stiffness
25 : 30 % Age 25-29 year
Up to 50 %

Age over 45 year
Neck Stiffness with Brachialgia
5 : 10 % Age 25 – 29 year
25:40 % Age over 50
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Causes

Causes

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Musculosketetal Causes Osteoarthritis Diffuse idiopathic skeletal hyperstosis Cervical spondylosis Disk disease

Musculosketetal Causes

Osteoarthritis
Diffuse idiopathic skeletal hyperstosis
Cervical spondylosis
Disk disease
Rheumatoid arthritis
Fracture
Neoplasm
Thoracic outlet syndrome (cervical

rib, first rib,and clavicular compression syndromes)
Osteomyelitis
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Neurological Causes Nerve root syndromes Cervical myelopathy Neuritis (brachial,occipital) Torticollis Meningitis Cord tumors

Neurological Causes

Nerve root syndromes
Cervical myelopathy
Neuritis (brachial,occipital)
Torticollis
Meningitis
Cord tumors

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Soft tissue and muscular pain Acute cervical strain Cumulative trauma, overstrain

Soft tissue and muscular pain

Acute cervical strain
Cumulative trauma, overstrain syndromes
Tendinitis, bursitis
Postural

disorders
Fibrositis, fibromyalgia, and myofascial syndrome
Pharyngeal infection
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Referred Pain Heart and coronary artery disease Apex of lung: Pancoast’s

Referred Pain

Heart and coronary artery disease
Apex of lung: Pancoast’s tumor
Migraine
Muscle tension

and myofascial pain
TMJ syndrome
Diaphragm, gallbladder, pancreas, hiatus hernia
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AIM Relief of pain and stiffness in the neck and arms

AIM

Relief of pain and stiffness in the neck and arms
Restore

the function of neck and related structures .
Avoid pain recurrence
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Early mobilization exercises in patients with acute sprains often improve outcome

Early mobilization exercises in patients with acute sprains
often improve outcome


Bed rest should be reserved for severe acute cases

Facts

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HAND BOOK توعيه المريض

HAND
BOOK

توعيه
المريض

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التمرينات اليوميه بالمنزل

التمرينات اليوميه بالمنزل

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Traction Traction forces over 9kg cause separation of 1- 1.5 mm

Traction

Traction forces over 9kg cause
separation of 1- 1.5 mm at

each
posterior vertebral level
It is greatest with the neck in flexion
9-11 kg flattens the normal lordosis
Rhythmic traction produces more separation than sustained traction
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PROF. SUN RISE (SHARM.) BY DR /REDA AWAD REDA AWAD AT

PROF.

SUN RISE (SHARM.)
BY
DR /REDA AWAD

REDA AWAD

AT AGOUZA

SPECIALISED
SPINE CENTER
(ASSC)

UP DATE
MANAGEMENT OF
BACK PAIN

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LBP: Statistics Second only to the common cold in frequency among

LBP: Statistics

Second only to the common cold in frequency among adult

ailments
Fifth most common reason for an office visit
Source of LBP is “mechanical” in 90% and the prognosis is good
Acute: 50% are better in 1 week;
90% have resolved within 8 weeks
Chronic: <5% of acute low back pain progresses to chronic pain (6 month)
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.. Up to 50% of working adults have back pain each

.. Up to 50% of working adults have back pain each

year.

Lifetime recurrence rates of as high as 85% have been documented.

80% of all people experience low back pain at some time.

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The disc is made up of three basic structures: the nucleus

The disc is made up of three basic structures: the nucleus pulposus,


the annulus fibrosus and the vertebral end-plates,
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Disc innervation 1981 Australian clinical anatomist and physician Nikoli Bogduk The

Disc innervation

1981 Australian clinical anatomist and physician Nikoli Bogduk
The outer 1/3

of annulus receive innervation with small afferents.
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interadiscal pressure

interadiscal pressure

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is a synovial joint between the superior articular process, of one

 is a synovial joint between the superior articular process, of one vertebra and the inferior articular

process of the vertebra directly above it.

facet joint

These joints are in constant motion, providing the spine with both the stability and flexibility

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Degeneration Before age 40 approximately 25%. Beyond age 40, more than

Degeneration
Before age 40 approximately 25%. Beyond age 40, more than 60%

of people show evidence of disc degeneration at one or more levels on a MRI.
the nucleus pulposus begins to dehydrate and the concentration of proteoglycans in the matrix decreases, thus limiting the ability of the disc to absorb shock.
The anulus fibrosus also becomes weaker with age and has an increased risk of tearing.
In addition, the cartilage end plates begin thinning, fissures begin to form, and there is sclerosis of the subchondral bone
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As the disc dehydrates the disc loose ability to support the

As the disc dehydrates
the disc loose ability to support the

axial load of the body; this causes a 'weight bearing shift' from the nucleus, outward, onto facet joints . 
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bear the highest loads and tend to undergo the most motion.

bear the highest loads and tend to undergo the most motion.

Consequently, these areas are found to sustain the most spinal strain or sprain injuries

The L4-5 and L5-S1 areas

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The majority of spinal disc herniation cases occur in lumbar region

The majority of
spinal disc herniation cases occur in
 lumbar region
 (95% in

L4-L5 or L5-S1) 

posterolaterally,
where the anulus fibrosus is relatively thin and is not reinforced by the posterior longitudinal ligament

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Pain provoked behind knee By stretching of hamstrings Pain in the

Pain provoked behind knee
By stretching of hamstrings

Pain in the back provoked

past this
point

NORMAL

ABNORMAL

Thus the finding of a negative SLR sign is important in helping to "rule out" the possibility of a lower lumbar disc herniation

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Imaging studies should be ordered in patient with : - progressive

Imaging studies should be ordered in patient with :

- progressive neurologic

deficits

- failure to improve

- history of truma

- those at elevated risk for malignancy or infection

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herniated disc at the L5-S1 herniation (of the disc between the L4-L5

herniated disc at the L5-S1

herniation (of the disc between the L4-L5


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The Diagnosis of back pain should be Based on a Good

The Diagnosis of back pain should be
Based on a Good

History and
a Competent Physical examination
Clinical examination is the most important
Diagnostic procedure that will be undertaken
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Goals *Relieve of pain *Restoration of physiological movements *Prevention of relapses

Goals

*Relieve of pain

*Restoration
of physiological movements

*Prevention of relapses

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unless the patient has an acute or progressive neurological deficit. Approximately

unless the patient has
an acute or
progressive neurological deficit.

Approximately 90%


of acute sciatica
attacks improve with conservative management; such as treatment with

anti-inflammatory medications,
physical therapy, & lumbar injection,

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Surgery should be considered for Individuals With Motor Weakness . Persistant

Surgery should be considered for

Individuals With Motor Weakness

.

Persistant Radicular pain

Failure of Conservative therapy
at 3or more months .

Cauda equina syndrome .

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Other Treatment muscle relaxants or nonsteroidal anti-inflammatory drugs to control muscle

Other Treatment
muscle relaxants or
nonsteroidal anti-inflammatory drugs to control muscle spasms.


A lightweight lumbosacral corset may also be used to help control muscle spasms.
Use of the corset should be discontinued as soon as the spasms have resolved.
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The patient should also be instructed in the proper body mechanics with everyday tasks

The patient should also be instructed in the proper body mechanics

with everyday tasks
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modalities

modalities

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HAND BOOK

HAND
BOOK

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PERCUTANEOUS MINIMAL INVASIVE INTERVENTIONAL PAIN MANEGMENT OF LOW BACK PAIN

PERCUTANEOUS MINIMAL INVASIVE INTERVENTIONAL

PAIN MANEGMENT OF LOW BACK PAIN

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fluoroscopy CT DISCECTOMY

fluoroscopy

CT

DISCECTOMY

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AGOUZA SPECIALISED SPINE CENTER (ASSC)

AGOUZA
SPECIALISED SPINE CENTER
(ASSC)

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Electromyography Prof. Dr. Reda Awad

Electromyography

Prof. Dr. Reda Awad

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the normal neurophysiologic function of the nervous system. Electrical signals are

the normal neurophysiologic function of the nervous system.
Electrical signals are

generated in the brain, pass through the spinal cord, and travel into the peripheral nervous system.
These signals are carried down the nerve to the synaptic cleft, where a chemical release of acetylcholine crosses the synaptic cleft to create an electrical discharge in the muscle.
This electrical signal causes the muscle to contract
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Why It Is Done To help in the diagnosis&assessment of the

Why It Is Done
To help in the diagnosis&assessment of the diseases

that damage muscle tissue, nerves, or the junctions between nerve and muscle.
,.
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Electromyogram (EMG) and Nerve Conduction Studies An electromyogram (EMG) measures the

Electromyogram (EMG) and Nerve Conduction Studies
An electromyogram (EMG) measures the electrical

activity of muscles at rest and during contraction.
Nerve conduction studies measure how well and how fast the nerves can send electrical signals.
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Electromography and nerve conduction studies is an important and helpful Extension

Electromography and nerve conduction studies is an important and helpful Extension

of the physical examination and can detect minor abnormalities when physical examination cannot
In the assessment of the peripheral nervous system injuries.
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Key steps Review of referral materials Eliciting the patient’s history Performing

Key steps
Review of referral materials
Eliciting the patient’s history
Performing a physical

examination
Developing a differential diagnosis
Putting together a plan for electrodiagnostic evaluation
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Electromyography This procedure involves the placement of a needle into various

Electromyography
This procedure involves the placement of a needle into various muscles

to record different stages of muscle activity,including rest,
minimal contraction,
and maximal activity.
At rest, normal muscle is electrically silent.
Damaged muscle tissue may result in spontaneous depolarization of individual muscle fibers.
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EMG of normal muscle At rest: no activity. On minimal volition

EMG of normal muscle

At rest: no activity.
On minimal volition : MUAPs

are of average amplitude and duration. The polyphasic potentials are less than 10%.
On maximum volition : full interference pattern.
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The normal MUAP is usually biphasic or triphasic with amplitude range


The normal MUAP
is usually biphasic or triphasic with amplitude

range of 0.5 to 3 mV ,and a duration between 2 and 10 ms.
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Anatomical sites of involvement including possible aetiology Site Aetiology --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Anterior

Anatomical sites of involvement including possible aetiology

Site Aetiology
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Anterior horn cell poliomyelitis

motor neurone disease
Spinal muscular dystrophies
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Nereve root Prolapsed intervertebral disc
Traction injury.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Plexus penetrating wounds
Traction injury.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Peripheral n. Neuropathies including compression neuropathies
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Neuromuscular jun. Myasthenia Gravis.
Myasthenic syndrome.
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Muscle fibre Myopathies
Polymyositis
Myotonias
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Prof. Dr. Reda Awad

Prof. Dr. Reda Awad

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Motor nerve conduction studies Almost any nerve that has motor fibers

Motor nerve conduction studies

Almost any nerve that has motor fibers and

is placed superficially along a portion of its course can be stimulated with a surface electrode , and the distal muscle response can be recorded using another recording surface electrode.
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The Term Entrapment describes the mechanical irritation by which a specific

The Term Entrapment describes the mechanical irritation by which a specific

peripheral nerve becomes locally injured in a vulnerable anatomic site

Familiarity with the Anatomy of the peripheral Nerves is essential.

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Nerve compression Can Occur at any point where a peripheral nerve

Nerve compression Can Occur at any point where a peripheral nerve

passes through
An opening In fibrous tissue or through
An Osseo fibrous Canal.
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In addition to a neurologic examination, the evaluation of every patient

In addition to a
neurologic examination,
the evaluation of every patient

with an entrapment neuropathy should include
electromyography (EMG) motor and sensory nerve conduction velocity studies,
and appropriate radiographs
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EMG and nerve conduction velocity measurements provide localizing information often necessary

EMG and nerve conduction velocity measurements provide localizing information often necessary

in the early diagnosis of a compressive neuropathy and reliably document the severity and extent of nerve entrapment
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Classification of nerve injuries Neurapraxia: It is a comparatively mild injury

Classification of nerve injuries

Neurapraxia: It is a comparatively mild injury with

motor and sensory loss with no evidence of Wallerian degeneration. The nerve distally conducts normally. Focal demyelination and/or ischemia are thought to be the aetiology of the conduction block.
Recovery may occur within hours, days, weeks, or up to a few months.
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Axonotmesis: It is commonly seen in crush injuries The axon and

Axonotmesis:
It is commonly seen in crush injuries The axon and

their myelin sheaths are broken, yet the surrounding stroma remains partially or fully intact.
Wallerian degeneration occurs, but subsequent axonal regrowth may proceed along the intact endoneurial tubes.
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Neurotemesis It describes a nerve that has been either completely served

Neurotemesis
It describes a nerve that has been either completely served or

is so markedly disorganized by scar tissue that axonal regrowth is impossible.
Prognosis for spontaneous recovery is extremely poor without surgical intervention.
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Characteristic features associated with Various nerve compressions

Characteristic features associated with Various nerve compressions

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What Is Carpal Tunnel Syndrome?

What Is
Carpal Tunnel Syndrome?

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* R . A * Hypothyroidism * Amyloidosis * Gout *

   * R . A
    * Hypothyroidism
    * Amyloidosis
    *

Gout
    * Acromegaly
    * Pregnancy
    * Teno synovitis

Causes

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* Mixed sensor motor N. * Sensory - paresthesias * Motor

* Mixed sensor motor N.
* Sensory - paresthesias
*

Motor - weakness and atrophy of the theanr muscles

* The discomfort worsens at night and often awakens her from sleep.
* Frequently bilateral.

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If sever , the CTS may produce retro grade pain to

If sever , the CTS may produce retro grade pain to

the forearm and less commonly to the shoulder and neck regions .
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Double crush syndrome of the MEDIAN nerve

Double crush syndrome of the MEDIAN nerve

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Treatment: Nonoperative: Splint the limb in the neutral position that maximize

Treatment: Nonoperative: Splint the limb in the neutral position that maximize

space for the entrapped nerve. Maintain good blood flow to the limb and reduce swellings and oedema in order to prevent the compression
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Rest the Wrist Wrist rests help to avoid carpal tunnel syndrome

Rest the Wrist Wrist rests help to avoid carpal tunnel syndrome by

keeping the wrists elevated above the keyboard. An Ergonomic Glove IMAK Products' Smart Glove uses a removable splint (upper cutout) to keep the wrist in the proper position. The ergoBeads (bottom cutout) massage the area to increase blood circulation and promote healthy muscle tissue. (Image courtesy of IMAK Products Corporation, www.imakproducts.com)
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Modify activity and avoid positions that can be a source of

Modify activity and avoid positions that can be a source

of trauma. Reduce inflammation and consider the use of ice,NSAIDs and corticosteroid injection in structures around the nerves that may be inflammed
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Operative: If despite of nonoperative treatment,there is evidence of continuing axonal

Operative: If despite of nonoperative treatment,there is evidence of continuing axonal

degeneration in the entrapped nerve,surgical decompression of the nerve is considered
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*surgery produces good results in cases caused by ganglion , some

*surgery
produces good results in cases caused by ganglion , some

selected causes of truma and R .A .
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Anky losing spondy litis Is a chronic systemic inflammatory disorder of

Anky losing spondy litis

Is a chronic systemic inflammatory disorder of

undetermined etiology
Usually beginning in early adulthood
Primarily affecting the axial skeleton
often with enthesopathy
Extra articular features can also exhibit
The disease prevalence in adult population is close to 0.2%
male to female ratio is 3 : 1

generally begins in the sacroiliac joint

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Eyes Acute Anterior Uveitis 25 – 45 % Skin Psoriasis &

Eyes
Acute Anterior Uveitis
25 – 45 %

Skin
Psoriasis & Nail Changes
5 – 16

%

Gut
IBD 5 – 8 %,
(Microscopic lesion 22 – 69 %)

Axial Disease,
Peripheral Arthritis,
Enthesitis, Dactylitis
Osteopenia/Osteoporosis
19 – 62 %

Lungs
Restrictive Lung Disease,
Apical Fibrocystic Disease 1 – 1.3 %
Heart
Aortic Insufficiency, Heart Block
2 – 3 %
Kidneys
IgA nephropathy, Amyloidosis 0.3– 1.2 %
Cauda Equina Syndrome
0.5 %
Spinal Ankylosis
Fracture

Axial SpA/AS and Associated Manifestations/Extra-articular

Khan MA. Spondyloarthropathies: clinical features of AS. In: Hochberg M, et al., eds. Rheumatology 3rd ed. Edinburgh, Scotland: Mosby;2003:1161–1170; Khan MA. Ankylosing Spondylitis. New York. OUP. 2009; Lautermann D, Braun J. Clin Exp Rheum. 2002;6(suppl 28):S11–S15; Magrey M, Khan MA. Osteoporosis in AS. Curr Rheumatol Rep. 2010 Aug 3. [Epub ahead of print]; Arends S. Arthritis Res Ther. 2012 Apr 30;14(2):R98. doi: 10.1186/ar3823; Smale S, et al.Arthritis Rheum. 2001;44(12):2728–2736; Rodrigues CE, et al. Rev Bras Rheumatol. 2012 Jun;52(3):379-383.

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ETIOLOGY, PATHOGENESIS AND PATHOLOGY Key initial inflammatory lesions occur at FIBROCARTILAGINOUS

ETIOLOGY, PATHOGENESIS AND PATHOLOGY

Key initial inflammatory lesions occur at FIBROCARTILAGINOUS ENTHESES

rich in aggrecans and type II collagen

(e.g. intervertebral disc, sacroiliac joint, symphysis pubis and root of aorta)

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Disease Progression in AS Obliteration of lumbar lordosis with atrophy of

Disease Progression in AS

Obliteration of lumbar lordosis with atrophy of

buttocks
Accentuation of thoracic kyphosis
Forward stoop of neck if the cervical spine is involved
Hip involvement
Flexion contractures
Compensated
for by knee flexion
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Inflammatory Back Pain according to experts* * * * Insidious onset

Inflammatory Back Pain according to experts*

*

*

*

Insidious onset
Pain at night(with

improvement upon getting up
Age at onset <40 years
Improvement with exercise
No improvement with rest

*Sieper J, et al. Ann Rheum Dis. 2009; 68(6):784-8. Rudwaleit M, et al. ARD. 2009; 68(6):777-83.
**Ozgocmen S, Akgul O, Khan MA. Mnemonic for ASAS criteria. J Rheumatol. 2010 Sep;37(9):1978-9.

** Mnemonic “IPAIN”© or “iPAIN”©

In fact, the confirmation of IBP is the most widely accepted starting point for assessing the potential presence of an axial spondyloarthritis such as AS.1

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Signs painful sacro-iliac tests * limited spinal movements

Signs painful sacro-iliac tests * limited spinal movements

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Ankylosing Spondylitis Key Features: Low back pain Prolonged AM stiffness Nocturnal

Ankylosing Spondylitis

Key Features:
Low back pain
Prolonged AM stiffness
Nocturnal stiffness
Improves with exercise
Xrays with

signs of sacroiliitis
-Ensethopathy
-Positive Family History.
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Ankylosing Spondylitis is a disease charactrized by early onset& delayed diagnosis

Ankylosing Spondylitis is a disease charactrized by early onset& delayed diagnosis

Clearly

there is a significant gap between
Onset and diagnosis
(8-9 years)

Khan M Arthritis Rheum Dis 2000;61(Suppl III):iii3-iii7.

Feldtkeller E, et al. Rheumatol Int. 2003;23:61-6

Age of
Onset

Age at Diagnosis

Age in years

Males (N=920)
Females (N=476)

Age of Onset and Diagnosis in AS

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Why is Early Diagnosis of AS Important? Improved diagnostic tools (MRI)

Why is Early Diagnosis of AS Important?

Improved diagnostic tools (MRI) and

advances in genetic screening make early diagnosis more reliable
New effective treatments are available

Khan M Arthritis Rheum Dis 2000;61(Suppl III):iii3-iii7.

Spinal damage is cumulative, irreversible&, independent of symptoms.

81% of AS patients lose spinal mobility in the first 10 years of disease

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Education, exercise, physical therapy, rehabilitation, patient associations, self help groups NSAIDs

Education, exercise, physical therapy, rehabilitation, patient
associations, self help groups

NSAIDs

Peripheral disease

Axial


disease

Sulfasalazine

TNF blockers

Ana
l
ges
i
cs

Local corticosteroids

Su
r
ge
r
y

Zochling J et al. Ann Rheum Dis 2005 Aug 26; [Epub ahead of print]

ASAS/EULAR recommendations for the management of AS

Слайд 130

Ankylosing spondylitis use NSAIDs About 60-75% of patients with AS show

Ankylosing spondylitis use NSAIDs

About 60-75% of patients with AS show good

to very good response to full dose NSAIDs in 48 hours , in contrast with only 15% of patients with mechanical back pain.
Recent study has shown that patients with AS treated continuously over two years with a daily dose of NSAIDs has
less radiological progression compare to those who took NSAIDs on demand
Arth Rheum 2005;52-1756-65
Слайд 131

20-50% of AS patients still have active disease despite treatment with

20-50% of AS patients still have active disease despite treatment with

NSAID..
For those patients , Anti-TNF have meant a breakthrough in treatment
Слайд 132

Spinal Inflammation in AS Before and After Treatment With TNF blockers

Spinal Inflammation in AS Before and After Treatment With TNF blockers


Braun J, et al. Arthritis Rheum. 2006;54:1646-1652.

ASSERT MRI Study

Almost complete resolution of spinal inflammation was seen in most patients

Слайд 133

PRINCIPLES OF MANGEMENT OF AS 1- No cure , but most

PRINCIPLES OF MANGEMENT OF AS

1- No cure , but most

patients can be well managed

2- Early diagnosis is very important

3- Education to increase compliance

4- Appropriate use of antirheumatic drugs ,primarily (NSAIDs)and appropriate use of biologic therapy

Слайд 134

5- Continuity of care 6- Daily exercise very important (e.g., swimming

5- Continuity of care

6- Daily exercise very important (e.g., swimming

)

7- Sleep on firm mattress

8-Avoidance of smoking & trauma

Слайд 135

A full explanation of the disease , its course , possible

A full explanation of the disease , its course , possible

complications, its manegment& prognosis is essential to achieve appropriate compliance by the patient
Слайд 136

* Lying prone for 15 to 30 minutes once or several

* Lying prone for 15 to 30 minutes once or several

times a day is useful to reverse the tendency toward kyphosis , and flexion contractures of the hip joints
Слайд 137

PHYSIOTHERAPY * In a randomized controlled trial , a program of

PHYSIOTHERAPY

* In a randomized controlled trial , a program of

supervised physiotherapy in groups was found to be superior to individualized programs in improving thoracolumbar mobility and fitness
Слайд 138

A New Therapeutic Approach Is Needed for AS Eeeeeer Early, aggressive

A New Therapeutic Approach Is Needed for AS
Eeeeeer
Early, aggressive therapy &early introduction

of biologic
can yield
Less structural damage
Better function
Remission

Early diagnosis is critical!
Early use `of biologic
Lead to:

Слайд 139

Слайд 140

Osteoporosis PROF/ REDA AWAD

Osteoporosis

PROF/
REDA AWAD

Слайд 141

Osteoporosis ("porous bones", from Greek: ὀστέον/ osteon meaning "bone" and πόρος/poros meaning "pore")

Osteoporosis
("porous bones",
from Greek: ὀστέον/
osteon meaning "bone" and πόρος/poros meaning

"pore")
Слайд 142

بسم الله الرحمن الرحيم ” قال رب إني وهن العظم مني

بسم الله الرحمن الرحيم ” قال رب إني وهن العظم مني

و اشتعل الرأس شيباً و لم أكن بدعائِك رب شقياً “ صدق الله العظيم سورة مريم(4)
Слайд 143

International statistics Osteoporosis is by far the most common metabolic bone

International statistics
Osteoporosis is by far the most common metabolic bone disease

in the world and is estimated to affect over 200 million people worldwide.
One in 3 women older than 50 years will eventually experience osteoporotic fractures, as will 1 in 5 Men
Слайд 144

Слайд 145

أن العظم نسيج حيّ. يتكون في معظمه من الكولاجين وهو البروتين


أن العظم نسيج حيّ. يتكون في معظمه من الكولاجين وهو البروتين

الذي
يشكل الهيكل اللين للعظم، ومن فوسفات الكالسيوم الذي يمنح هذا الهيكل صلابته المعروفة. 

املاح 65%


بروتين 35%

خلايا
تزيل * تبنى

Слайд 146

العظم نسيج حى فى حركه نشطه دائمه فيتم ازاله العظم القديم

العظم نسيج حى فى حركه نشطه دائمه فيتم ازاله العظم القديم

ليحل مكانه عظم جديد.
تواصل عظامنا
عملية ترميم دائمة تستمر مدى الحياة.

Modeling تشكيل &
اعاده تشكيل Remodeling تتاثر هذه العمليه بالهرمونات وبعض العوامل الاخرى

Слайд 147

Bone is continuously turned over by Modeling & Remodeling The rates

Bone is continuously turned over by Modeling & Remodeling The

rates of which are under hormonal, cytokines, & mechanical influence
Слайд 148

osteoclasts - عمر الخليه الهدامه اسبوعين . osteoblasts عمر الخليه البنائه

osteoclasts - عمر الخليه الهدامه اسبوعين
. osteoblasts عمر الخليه البنائه ثلاث

اشهر
.

عمليه
ترميم
العظام

عمليه
مستمره
مدى
الحياه

Слайд 149

Bone Modeling and Remodeling Bone modeling involves both the growth and

Bone Modeling and Remodeling

Bone modeling
involves both the growth and

shaping of bones. It occurs during the first two decades of life while growth plates remain open.
It involves both bone formation and resorption, the former exceeds the latter and is not coupled to it, as in bone remodeling.
[ Compston., 2001]
Слайд 150

خلال الطفولة والنمو، تكون سرعة تكوين العظم أكثر من سرعة إزالته.

خلال الطفولة والنمو، تكون سرعة تكوين العظم أكثر من سرعة إزالته.

وبعد ذلك يبدأ الجسم بإزالة النسيج العظمي القديم بسرعة أكبر من سرعة توليد النسيج العظمي الجديد

إن الفرد الذي لا يحصل على كتلة عظم مثالية في فترة بناء العظم القصوى التي تبدأ منذ الولادة وحتى سن الثلاثين تقريبا قد يتعرض لهشاشه العظام

بناء سريع

هدم بطئ

هدم سريع

هدم عادى

Слайд 151

Once the skeleton has reached maturity, regeneration continues in the form


Once the skeleton has reached maturity, regeneration continues in the form

of a periodic replacement of old bone with new at the same location. This process is called remodeling, and is responsible for the
((complete regeneration of the adult skeleton every 10 years)).
[ Compston., 2001 ]
Слайд 152

In the uninjured adult skeleton, all osteoclasts and osteoblasts belong to

In the uninjured adult skeleton, all osteoclasts and osteoblasts belong to

a unique temporary structure, known as:
Basic Multicellular Unit ( BMU )
The BMU, approximately 1–2 mm long and 0.2 – 0.4 mm wide, comprises a team of osteoclasts in the front, a team of osteoblasts in the rear, a central vascular capillary, a nerve supply, and associated connective tissue .
Слайд 153

In healthy human adults, 3–4 million BMUs are initiated per year

In healthy human adults, 3–4 million BMUs are initiated per year

and at least One million are operating at any moment .
Each BMU begins at a particular place and time toward a target, which is a region of bone in need of replacement.
[ Manolagas., 2000]
Слайд 154

الحاله الطبيعيه حاله الهشاشه

الحاله الطبيعيه

حاله الهشاشه

Слайд 155

A condition characterized by reduced bone mineral density and increased bone

A condition characterized by reduced bone mineral density and increased bone

fragility, resulting in bone fractures.

Normal trabecular bone

Osteoporotic bone

Osteoporosis - Definition

1. Feskanich et al. JAMA. 2002, 288:2300-2306.

Слайд 156

In 70 % of patients with osteoporosis the cause is primary

In 70 % of patients with osteoporosis the cause is primary

1

Caplan et al. J Royal Soc Med. 1994, 87:200-202.
Kok C. & Sambrook P.N. Best Practice & Research Clinical Rheumatology. 2009, 23:769-779.

Primary Osteoporosis

Secondary Osteoporosis

Primary osteoporosis
is caused by
post-menopausal bone loss or
age-related
bone loss 2

Слайд 157

Postmenopausal bone loss Curves of bone loss with progress of age (Remagen W, 1990)

Postmenopausal bone loss Curves of bone loss with progress of age

(Remagen W,

1990)
Слайд 158

Слайд 159

High Risk Factors for Fractures Low intake of Calcium + Vitamin

High Risk Factors for Fractures

Low intake of Calcium + Vitamin D3
Low

intake of Protein
Lack of exposure to sunlight
Low physical activity
Smoking
Alcohol
Coffee
Слайд 160

Osteoporosis Risk Factors & Prevention Fixed Risk Factors: Age Female gender

Osteoporosis Risk Factors & Prevention

Fixed Risk Factors:
Age
Female gender
Family history
Previous fracture
Race/ethnicity
Menopause/ hysterectomy
Long

term glucocorticoid therapy

Modifiable Risk Factors:
Low calcium intake
Vitamin D deficiency
Poor nutrition
Eating disorders
Lack of exercise
Frequent falls
Low body mass index
Smoking
Alcohol

” A diet rich in calcium and vitamin D and weight-bearing exercise help promote bone mineral density.”

http://www.iofbonehealth.org/ [ accessed 2008]

Слайд 161

Most common fracture sites Vertebra Wrist Hip

Most common fracture sites

Vertebra

Wrist

Hip

Слайд 162

Diagnostic methods Osteoporosis is diagnosed using: DXA x-ray Bone biopsy 1. Kanis. Osteoporos Int. 1997, 7:390-406.

Diagnostic methods

Osteoporosis is diagnosed using:
DXA
x-ray
Bone biopsy

1. Kanis. Osteoporos Int. 1997, 7:390-406.


Слайд 163

The most common way to diagnose osteoporosis is through a bone

The most common way to diagnose osteoporosis is through a bone

density scan

Dual energy x-ray absorptiometry (DXA) :
used for the whole body, spine, hip, heel and/or forearm
Measurement of BMD by DXA is currently the cornerstone for diagnosis of osteoporosis
today’s gold standard of osteoporosis detection

Слайд 164

T-score T-score is useful for the expression of BMD ( bone

T-score

T-score is useful for the expression of BMD
( bone mineral density)


T-score indicates the difference between a patient’s BMD and the ideal BM achieved by a young adult

1. Blake & Fogelman. Curr Pharm Des. 2002, 8:1885-1905.

= measured BMD – mean young adult BMD

young adult SD

Слайд 165

Osteoporosis: BMD of A BMD of classified as Osteoporosis

Osteoporosis: BMD of < -2,5

A BMD of < -2,5 is officially


classified as Osteoporosis
Слайд 166

Bone Biopsy Bone biopsy can be used to identify osteoporosis. A

Bone Biopsy

Bone biopsy can be used to identify osteoporosis.
A small sample

of bone is removed from the iliac crest.
Слайд 167

Quick Osteoporosis Risk Test for Women >50 7. Regulary Smoker 6.

Quick Osteoporosis Risk Test for Women >50

7. Regulary Smoker

6. Loss of

height or change of posture within last 5 years

5. Thin/ Underweight

1. Menopause before age 45

2. Family History of Osteoporosis

4. Treated with Corticosteroids or for Rheumatoid Arthritis

3. Any Fractures after age 50

8. Low Calcium Intake*

If you have answered Yes to 3 or more of the above, you may be at risk of Osteoporosis

Yes

No

Yes

No

Yes

No

Yes

No

Yes

No

Yes

No

Yes

No

Yes

No

* Recommended daily intake of 1000-1500 mg of calcium = 4-6 glasses of milk (www.iofbonehealth.org/patients-public/calcium-calculator.html)

Слайд 168

Diagnosing osteoporosis is usually a combination of BMD, Age, previous fractures & history of falls

Diagnosing osteoporosis is usually a combination of BMD, Age, previous fractures

& history of falls
Слайд 169

Osteoporosis: Underdiagnosis

Osteoporosis: Underdiagnosis

Слайд 170

Osteoporosis: ‘the silent epidemic’ Half of all patients: may be asymptomatic

Osteoporosis: ‘the silent epidemic’

Half of all patients:
may be asymptomatic
are not

aware that they are suffering from osteoporosis before they suffer a fracture
Only 1/3 vertebral fractures come to medical attention1,2

1. Cooper C. In: Reid (ed). Baillière’s clinical rheumatology. 1993, 7:459-477.
2. Delmas PD, Fraser M. European Union challenges member states to fight the ‘silent
epidemic’ of osteoporosis. Eurohealth 1998, 4:1-4.

Слайд 171

Most Common Symptoms of Osteoporosis Low back pain Loss of height

Most Common Symptoms of Osteoporosis

Low back pain
Loss of height
Stooped posture

If calcium

is subnormal for long periods of time (many months or years) then problems with dry skin and hair, brittle nails and chronic tiredness may occur
Слайд 172

Osteoporosis - Clinical Consequences Kyphosis (stooped posture) Loss of height Bulging

Osteoporosis - Clinical Consequences

Kyphosis (stooped posture)
Loss of height
Bulging abdomen (

for some the ribcage rides on the iliac crest )
Acute and chronic pain
Breathing difficulties, reflux and other GI symptoms
Fear of falls
Depression

REDUCED QUALITY OF LIFE

Слайд 173

Osteoporosis: Treatment Options & Guidelines

Osteoporosis: Treatment Options & Guidelines

Слайд 174

Management of osteoporosis Ways to reduce fracture risk calcium and vitamin

Management of osteoporosis Ways to reduce fracture risk

calcium and vitamin D

rich diet
medication
less alcohol
exposure to sunlight
exercise
stop smoking
hip protectors
Слайд 175

Calcium + Vitamin D is the fundamental part of any Osteoporosis

Calcium + Vitamin D is the fundamental part of any Osteoporosis

Treatment

Calcium + Vitamin D

Bisphosphonates

Calcitonin

SERMS

HRT

PTH

Strontium Ranelate

Denosumab

Baseline Treatment

Calcium + Vitamin D3 is normally used as first-line treatment either alone or in combination with other Osteoporosis medicines

IOF online: http://www.iofbonehealth.org/health-professionals/about-osteoporosis/treatment/calcium-vitamin-d.html

Слайд 176

الجرعه اليوميه للكالسيوم --(غذاء وادويه1,200-1,500 mg Take calcium supplements in doses

الجرعه اليوميه للكالسيوم
--(غذاء وادويه1,200-1,500 mg
Take calcium supplements in doses

of
less than 600 mg. the body can only absorb so much at one timeقرص بعد الفطار والغذاء.
D الجرعه اليوميه لفيتامين
800-1,000 IU

فيتامين D ضروري للحصول على الامتصاص المثالي للكالسيوم.

Слайд 177

Слайд 178

برنامج الوقايه من مرض هشاشه العظام غذاء متوازن غنى بالكالسيوم وفيتامين

برنامج الوقايه من مرض هشاشه العظام

غذاء متوازن غنى بالكالسيوم وفيتامين د


برنامج رياضى(المشى والتمرينات)

لا تدخين ولا كحول

دواء لعلاج الهشاشه عند الاحتياج

Слайд 179

منع السقوط 1تاكد من الابصار الجيد (تصحيح النظر) ---- والاضاءه جيده

منع السقوط

1تاكد من الابصار الجيد (تصحيح النظر) ---- والاضاءه جيده
2 تجنب

الادويه المنومه
3 ازاله معوقات المشى من المنزل(السجاد –الاثاث)
4الحذاء مريح ومثبت جيدا بالقدم
5استعمال سواند الحائط عند اللزوم
Слайд 180

Слайд 181

weight – bearing aerobic activity

weight – bearing aerobic activity