Содержание
- 2. According to WHO, cardiovascular diseases today occupy fifth place in the structure of global mortality, and,
- 4. lipoprotein (a) is an LDL particle whit an apolipoprotein (a) attached to it. it is involved
- 5. A single copy of apo(a) is linked to apo B-100 via a disulphide bond . Apo(a)
- 6. One in five people has high levels of Lip(a) from birth based on genetic factors they
- 7. The apo(a) component of Lp(a) particle promotes the process of atherogenesis , in part , due
- 10. SCREENING
- 11. There are specific conditions that can increase the amount of Lp(a) in your body. Estrogen depletion
- 12. For 10_ 12 hours before test Types of Lp(a) assay Sandwich ELISA ( enzyme-linked immunosorbent assay
- 14. Скачать презентацию
According to WHO, cardiovascular diseases today occupy fifth place in the
According to WHO, cardiovascular diseases today occupy fifth place in the
In the past quarter century, Kazakhstan has the highest mortality rate from diseases of the circulatory system among the countries of the European Union, Central and Eastern Europe and Central Asia region. According to the Institute of Cardiology and Internal Diseases Republic of Kazakhstan, the death rate from diseases of the circulatory system in our country for a long time reached a terrifying figure - 500-600 cases per 100 thousand population. Almost two million people are registered in the republic suffering from cardiovascular diseases. This is 12% of the population!
Cardiovascular disease mortality in 2015
lipoprotein (a) is an LDL particle whit an apolipoprotein (a) attached
lipoprotein (a) is an LDL particle whit an apolipoprotein (a) attached
Lp(a) accumulates in atherosclerotic plaque and its plasma concentration is predictive of heart disease in many patients . Because the density of Lp(a) overlaps that of dense LDL and buoyant HDL , separation of Lp(a) by density alone is inherently difficult . For this reasons , it is important to measure Lp(a) directly whit a specific Lp(a) assay in order to get truly accurate results.
LDL
Lp(a)
A single copy of apo(a) is linked to apo B-100 via
A single copy of apo(a) is linked to apo B-100 via
Apo(a) comprises a series of loop structure called kringles, the LPA gene which codes for apo(a) was derived from the coding for plasminogen during evolution .
One in five people has high levels of Lip(a) from birth
One in five people has high levels of Lip(a) from birth
Important facts about Lip(a)
High Lip(a) is not rare. One in five people globally and 63 million people in the U.S. have high Lip(a) levels, and most do not know they are at risk.
High Lip(a) is the strongest, single, inherited risk factor for early coronary artery disease (CAD) and aortic stenosis, or narrowing of the aorta.
People living with high Lip(a) have a 2-4 times higher risk of early heart and blood vessel disease compared to people with normal Lip(a) levels.
High Lip(a) occurs in all ethnic groups, but is more common among African Americans and South Asians.
The apo(a) component of Lp(a) particle promotes the process of atherogenesis
The apo(a) component of Lp(a) particle promotes the process of atherogenesis
This interference results from apo(a) binding to plasminogen binding sites preventing plasminogen and t-PA from interacting . If t-PA cannot cleave plasminogen to plasmin then fibrin clots cannot be dissolved .
Lp(a) also interferes whit plasmin binding sites on the fibrin clot which also interferes whit the process of clot dissolution all of which leads to enhanced atherogenesis .
The green arrows indicated enhanced activity such as the ability of Lp(a) to increase the production and activity of PAI-1.
Red T- lines represent inhibitory processes
Role of Lp(a) in promotion of atherogenesis
SCREENING
SCREENING
There are specific conditions that can increase the amount of Lp(a)
There are specific conditions that can increase the amount of Lp(a)
Estrogen depletion
Hypercholesterolemia
Hypothyroidism
Uncontrolled diabetes
Renal failure
Nephrotic syndrome
For 10_ 12 hours before test
Types of Lp(a) assay
Sandwich ELISA (
For 10_ 12 hours before test
Types of Lp(a) assay
Sandwich ELISA (
Non – competitive ELISA
Latex immunoassay
Immunonephlometric
Immunoturbidometric
Fluorescence immunoassay
Elictroimmunodiffusion