Содержание
- 2. Plan Definition Laboratory methods and their description DIC scoring system Conclusion
- 3. Disseminated Intravascular Coagulation Definition Is considered an “acquired bleeding disorder” Is not a disease entity but
- 4. Hemostatic Balance ATIII Clotting Factors Tissue factor* PAI-1 Antiplasmin TFPI Prot. C Prot. S Procoagulant Anticoagulant
- 5. SYSTEMIC ACTIVATION OF COAGULATION Intravascular deposition of fibrin Depletion of platelets and coagulation factors Thrombosis of
- 6. Conditions Associated With DIC Infectious/Septicemia Bacterial Gm - / Gm + Viral CMV Varicella Hepatitis Fungal
- 7. Laboratory studies used in the diagnosis and evaluation of patients with DIC need to reflect the
- 8. The severity and extent of DIC can change over time so laboratory testing is often performed
- 9. Platelet count is a sensitive (though not specific) sign of DIC. Thrombocytopenia is a feature in
- 10. Fibrin degradation products and D-dimers Detection of neo-antigens on degraded cross linked fibrin It is important
- 11. Prothrombin time and activated partial thromboplastin time the PT and aPTT are normal or even shortened.
- 12. Fibrinogen Fibrinogen acts as an acute-phase reactant and despite ongoing consumption, plasma levels can remain well
- 13. Blood film Fragments Schistocytes Paucity of platelets
- 14. Other markers of haemostasis The natural anticoagulants antithrombin and protein C are often reduced in DIC
- 15. Differential Diagnosis Severe liver failure Vitamin K deficiency Liver disease Thrombotic thrombocytopenic purpura Congenital abnormalities of
- 16. The ISTH Sub-Committee of the Scientific and Standardization Committee (SSC) on DIC has recommended the use
- 18. Laboratory diagnosis of DIC is based on tests that demonstrate activation of coagulation and consumption of
- 19. Conclusion Prothrombin and activated partial thromboplastin times are prolonged. Levels of fibrinogen and clotting factors (particularly
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