Содержание
- 2. Phylogenetic disorder of genetic system Genes with common profiles of the presence and absence in disparate
- 3. The hundreds of eukaryotic genomes now sequenced allow the tracking of the evolution of human genes,
- 4. Different classes of functional gene groups have distinct coevolution patterns The TCA cycle is an extreme
- 5. Systematic identification of genes that coevolve with known pathways and diseases In the mapping of genes
- 6. Many molecular pathways map to the same phylogenetic clusters as genes associated with specific human diseases.
- 7. Phylogenetic profiling identifies a new MITF‐associated factor While phylogenetic profiling could be used to seek the
- 8. By analyzing the conservation of human proteins across 87 species, we sorted proteins into clusters of
- 9. Phylogenetic profile analysis of genes sets with similar disease phenotypes Phylogenetic profile analysis has previously been
- 10. Phylogenetic profiling identifies ccdc105 as a meiosis‐specific chromatin localization gene Proteins that constitute components of specialized
- 11. Many genes that were thought to map to different diseases are actually coevolved together and mapped
- 12. Materials and methods Species database generation Protein‐coding sequences for human genes were downloaded using BioMart version
- 13. Calculation of the list of most correlated genes Pearson correlation coefficient (R ) was calculated using
- 14. Calculation of Co10 scores To test whether sets of functional annotated genes are significantly coevolved, we
- 15. Generation of binary phylogenetic profile and NPP with different organism sets To test for the effect
- 16. Generation of coevolved gene clusters For each protein A, we ranked the top 50 most correlated
- 17. High load can lead to a small population size, which in turn increases the accumulation of
- 18. MSigDB and HPO database The Molecular Signature Database (MSigDB v3.0) contains 6800 gene sets collected from
- 19. Plasmids pcDNA3‐MITF and PGL4.11‐TRPM1 promoter luciferase were described in previous publications. pSG5‐RBP‐Jk was kindly provided by
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