Генетика. Mendel’s laws. Genetic interections

Содержание

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QUESTIONS -Mendel's Laws: *Law of Dominans *Law of Segregation *Law of

QUESTIONS

-Mendel's Laws:
*Law of Dominans
*Law of Segregation
*Law of Independent

Assortment
-Genetic Interactions: allelic and non allelic
- Multiple Alleles
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Gregor Mendel was: a young priest a science and math teacher

Gregor Mendel was:

a young priest
a science and math teacher

Mendel formed

the foundation of genetics, the scientific study of heredity.
Gregor Mendel is a Father of Genetics
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What he did….. He used pea plants because they have many

What he did…..

He used pea plants because they have many traits

that exist in only two forms. (tall/short, green seed/yellow seed) and they were self pollinating
He decided to cross plants with opposite forms of a trait, for example, tall plants and short plants.
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He started with purebred (always produces offspring with the same form

He started with purebred (always produces offspring with the same form

of a trait as the parent)
By using purebreds he knew that the offspring's traits would always be identical to that of the parents.
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First Experiment (P generation) Crossed purebred tall plants with purebred short

First Experiment (P generation)

Crossed purebred tall plants with purebred short plants.

He called it the parental generation or P generation.
He called the offspring from this cross the first filial generation (F1) filial meaning “son of”.
In the F1 generation all the plants were tall. The shortness trait had disappeared.
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Monohybrid Cross Р А А а а х G А а F1 А а

Monohybrid Cross

Р

А А

а а

х

G

А

а

F1

А а

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Law of Dominance In a cross of parents that are pure

Law of Dominance

In a cross of parents that are pure

for contrasting traits, only one form of the trait will appear in the next generation. All the offspring will be heterozygous and express only the dominant trait.
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Next experiment He allowed the F1 plants to self pollinate In

Next experiment

He allowed the F1 plants to self pollinate
In the

F2 generation there was a mix of tall and short plants.
This occurred even though the parents were all tall.
He found that ¾ of the plants were tall and ¼ of the plants were short.
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F1 А а А а х G А А а а


F1

А а

А а

х

G

А

А

а

а

А а

А А

А а

а а

F2

А А

А а

А а

а

а

3 : 1(phenotype)

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Р А А а а х G А а F1 А

Р

А А

а а

х

G

А

а

F1

А а

А а

х

G

А

А

а

а

А а

А А

А а

а а

F2

А А

А

а

А а

а а

1 2 1

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Law of Segregation During the formation of gametes, the two alleles

Law of Segregation

During the formation of gametes, the two alleles resposible

for a trait separate from each other.
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Р АА ВВ аа bb х G АВ аb F1 Аа Bb 100% Dihybrid Cross

Р

АА ВВ

аа bb

х

G

АВ

аb

F1

Аа Bb
100%

Dihybrid Cross

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F1 Аа Bb Аа Bb х G AB Ab aB ab

F1

Аа Bb

Аа Bb

х

G

AB Ab aB ab

AB
Ab
aB
ab

AaBb

AaBB

AABb

AABB

Aabb

AaBb

AAbb

AABb

aaBb

aaBB

AaBb

AаBB

aabb

aaBb

Aabb

AaBb

9 3 3 1

F2

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Dihybrid Cross Law of Independent Assortment Alleles for different traits are

Dihybrid Cross Law of Independent Assortment

Alleles for different traits are passed to

offspring independently of one another
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He concluded that: individual factors must control the inheritance of traits

He concluded that:

individual factors must control the inheritance of traits in

peas.
They exist in pairs and the female parent contributes one factor while the male parent contributes the other.
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Today we call those factors that control traits genes. They call

Today we call those factors that control traits genes.
They call

the different forms of gene alleles
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ГЕНЕТИКА Genetic Interections

ГЕНЕТИКА

Genetic Interections

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The phenomen to alter the phenotypic expression of a gene by


The phenomen to alter the phenotypic expression of a gene

by the influence of other genes is called Interaction of Genes.
Allelic interaction – is interaction between two alleles of the same gene to change the phenotype:
- complete dominance,
- incomplete dominance,
- codominance,
- multiple alleles.
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Full Dominance – one of the alleles is dominant and the other recessive

Full Dominance – one of the alleles is dominant and the

other recessive
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Incomplete Dominance- the dominant gene fails to show complete dominancy and

Incomplete Dominance- the dominant gene fails to show complete dominancy and

the hybrids appear intermediate between the two parents. This was observed by Correns in the “Four o’clock plant Mirabilis jalаpa”.
Co – dominance: both the alleles are equally dominant and hence express themselves equally in a heterozygote.
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Characters of Multiple Alleles They always occupy the same locus in

Characters of Multiple Alleles

They always occupy the same locus in the

chromosome and influence the same character.
Only two members of such alleles are present at a time in a diploid.
The wild type allele is nearly always dominant while the other mutant alleles in the series may show dominance or there may be an intermediate phenotypic effect.

Multiple Alleles – more than two alleles of a gene occupying the same locus in a given pair of homologous chromosomes are called multiple alleles.

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Inheritance of blood groups in man. Blood group A Blood group

Inheritance of blood groups in man.
Blood group A Blood group

B
P ♀IAI0 × ♂IBIO

G IA IO IB IO
F1 IAIB(AB), IAIO(A), IBIO(B), IOIO(O)

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Human blood groups

Human blood groups

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Non-allelec interaction – is interaction between alleles of different genes present

Non-allelec interaction – is interaction between alleles of different genes

present on different chromosomes:
-Complementary Genes,
-Epistasis,
-Polygenic Inheritance.
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Complementary Genes – one must be present for the other to

Complementary Genes – one must be present for the other to

have an operative effect.

А_В_ – Red
ааВ_ – White
аавв – White
А_вв – White
P ♀AAbb × ♂aaBB
G Ab aB
F1 AaBв- 100% Red

P ♀AaBb × ♂AaBb
G AB, Ab, AB, Ab
aB, ab aB, ab
F 2 9 : 7
Red : White

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Epistasis Epistasis is an interactoin between two non-allelic genes in which

Epistasis

Epistasis is an interactoin between two non-allelic genes in which one

gene supresses the expression of another affecting the same character. The expressed gene is called epistatic, while the supressed gene is said to be hypostatic.
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Dominant Epistasis (13:3) in Poultry А_вв – Colored аавв – White

Dominant Epistasis (13:3) in Poultry
А_вв – Colored
аавв – White P ♀AaBb

× ♂AaBb
aaB_ - White G AB,Ab AB, Ab
A_B_ -White a aB,ab aB,ab
F2 13 : 3
Ratio white : colored
_____
P ♀AABB × ♂aabb
G AB ab
F 1 AaBb – 100% White
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Polygenic Inheritance – each gene has a certain amount of effect

Polygenic Inheritance – each gene has a certain amount of effect

and the more number of dominant genes, the more pronounced is the effect.
In such inheritance the complete expression of a trait is controlled by two or more genes.
A dominant allele of each gene contributes only a unit fraction of the traits and the total phenotypic expression is the sum total or additive or cumulative effect of the dominant alleles of genes or polygenes.
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Height in Man. А1А1А2А2А3А3 – 180 см а1а1а2а2а3а3 – 150 см А1а1А2а2А3а3 А1А1А2а2а3а3 165 см а1а1а2А2А3А3

Height in Man.
А1А1А2А2А3А3 – 180 см
а1а1а2а2а3а3 – 150 см
А1а1А2а2А3а3
А1А1А2а2а3а3 165

см
а1а1а2А2А3А3
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Pleiotropism. A single gene influences more then one phenotypic trait. The

Pleiotropism.

A single gene influences more then one phenotypic trait. The phenomenon

of multiple phenotypic expressions of a single gene is called pleiotropism.
In man a pleiotropic gene has a multiple effect causing a hereditary disease called phenylketonuria.