Содержание
- 2. Biochemistry of thyroid hormones Vytášek 2010
- 3. 3,5,3´-triiodothyronine (T3)
- 4. Thyroxine (T4) 3,5,3´,5´-tetraiodothyronine
- 5. Biosynthesis of thyroid hormones and iodine metabolismus Receptor for thyroid hormones and mechanisms of regulation of
- 6. Biosynthesis of thyroxine The main synthetized thyroid hormone is thyroxine, but triiodothyronine is tentimes more potent
- 7. Biosynthesis of thyroxine Thyreoglobulin, secreted into the lumen of thyroid gland, is iodinated in one or
- 8. Precursor molecule (Tyr) and intermediates (MIT, DIT) during thyroxine biosynthesis
- 9. Biosynthesis of T4 from DIT Next reaction of DIT leads probably to creation reactive radical of
- 10. Schematic draw of condensation of DIT
- 11. Secretion of thyroid hormones Endocytosis of iodinated thyreoglogulin from lumen into the cell Fusion of endocytic
- 13. Transport of thyroid hormones by blood Thyroid hormones are hydrophobic compounds and therefore they used for
- 14. Structural similarities among receptors for steroid and thyroid hormones
- 15. Mechanism of thyroid hormone action Receptors for thyroid hormones are nuclear and its affinity is tentimes
- 16. Mechanism of thyroid hormone action
- 17. Increased expression of proteins by thyroid hormones Glycerol 3-phosphate dehydrogenase – main component of glycerol 3-phosphate
- 18. Increased respiration during hyperthyreodism Increased synthesis of ATP – increased synthesis of cytochrome c oxidase –
- 19. Mechanisms increasing body temperature during hyperthyroidism Reducing efficiency of ATP synthesis - increased synthesis of glycerol
- 20. Control of thyroid hormone synthesis and secretion Pituitary hormone thyreotropin (TSH) upregulates activity of iodide pump
- 21. Model of TSH receptor
- 22. Myxedema (myxoedema) Hypothyreoid myxedema is specific form of skin edema Increased activity of connective tissues leads
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