Labmeeting paper. Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex

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13.09.2016 Portugues Lab meeting Daniil Markov

13.09.2016

Portugues Lab meeting

Daniil Markov

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13.09.2016 Portugues Lab meeting Hypothesis “The IO compares descending motor commands

13.09.2016

Portugues Lab meeting

Hypothesis

“The IO compares descending motor commands with information about

movement and detects mismatches”
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13.09.2016 Portugues Lab meeting Behavioral paradigm

13.09.2016

Portugues Lab meeting

Behavioral paradigm

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13.09.2016 Portugues Lab meeting Average discharge rate during different behaviors …

13.09.2016

Portugues Lab meeting

Average discharge rate during different behaviors

… is the same.

But the average discharge rate is a bad measure for the IO.
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13.09.2016 Portugues Lab meeting Reaching for a missing handle Almost no

13.09.2016

Portugues Lab meeting

Reaching for a missing handle

Almost no discharge related to

any particular
phase of the undisturbed reaching task

No discharge modulation during the multiple attempts to grasp the missing handle

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13.09.2016 Portugues Lab meeting Reaching for a missing handle Almost no

13.09.2016

Portugues Lab meeting

Reaching for a missing handle

Almost no discharge related to

any particular
phase of the undisturbed reaching task

No discharge modulation during the multiple attempts to grasp the missing handle

The same cells showed discharge increase when the limb was mechanically stimulated during stance

A mismatch between motor command and expected movement outcome is not sufficient to elicit olivary discharge; stimulation is required.

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13.09.2016 Portugues Lab meeting Responses to perturbations During stance all cells

13.09.2016

Portugues Lab meeting

Responses to perturbations

During stance all cells responded to tapping

with probability approaching 100 %

Almost no discharge related to any particular
phase of the undisturbed reaching task

rDAO cells didn’t respond to unexpected perturbation

PO cells and rMAO cells increased discharge probability after contact with the obstructing bar

Unexpected stimulus, but not the unexpected absence of stimulus, can activate IO cells in some of its subdivisions.

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13.09.2016 Portugues Lab meeting Responses of rMAO cell to perturbations at

13.09.2016

Portugues Lab meeting

Responses of rMAO cell to perturbations at different phases

of the task

Responses of some IO cells to unexpected perturbations depend on the phase of the behavior