Overview of immune system

Август 2, 2022

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Биология
Overview of immune system

Содержание

2. The immune system consist of two interconnected arms Innate immunity Detect molecular components shared with all
3. Innate immunity
4. Components of innate immunity
8. Pathogen recognition The receptors of the innate immune system recognize conserved pathogen-associated molecular patterns (PAMPs). Receptors
9. Protein recognition receptors:
10. Protein recognition receptors: Toll-like receptors
12. Protein recognition receptors: C-type lectin receptors
14. Cytokine Cytokine are broad family of small proteins (5-20 kDa) that are important in cell signaling.
17. Cytokine/anticytokine therapy Therapies have been developed with the express aim to block/inhibitor restore the activity of
18. Adaptive immune system
19. Major players T and B lymphocytes
22. Humoral immunity B cells 1)Fab region 2)Fc region 3)Heavy chain (blue) with one variable (VH) domain
23. Origen of diversity – alternative splicing
25. Function of antibodies Prevent adhesion of pathogens (bacteria and viruses) Neutralize toxins Opsonization of bacteria Complement
26. Adaptive immune system Cellular immunity
27. Cellular immunity
29. Origen of variation in TCR
30. How to know what happening in the cell?
31. MHC with peptide
32. Killer kiss
33. Cancer cells can inhibit T-cells
34. T-CAR
36. Скачать презентацию

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The immune system consist of two interconnected arms
Innate immunity
Detect molecular

components shared with all pathogens
Adaptive immunity
Molecular components (“antigenes”) specific to individual pathogen

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Innate immunity

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Components of innate immunity

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Pathogen recognition
The receptors of the innate immune system recognize conserved

pathogen-associated molecular patterns (PAMPs).
Receptors are called pattern-recognition receptors (PRRs)

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Protein recognition receptors:

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Protein recognition receptors: Toll-like receptors

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Protein recognition receptors: C-type lectin receptors

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Cytokine
Cytokine are broad family of small proteins
(5-20 kDa) that are

important in cell signaling.

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Cytokine/anticytokine therapy
Therapies have been developed with the express aim to block/inhibitor

restore the activity of specific cytokines.

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Adaptive immune system

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Major players T and B lymphocytes

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Humoral immunity B cells
1)Fab region
2)Fc region
3)Heavy chain (blue) with one variable (VH)

domain followed by a constant domain (CH1), a hinge region, and two more constant (CH2 and CH3) domains
4)Light chain (green) with one variable (VL) and one constant (CL) domain
5)
Antigen binding site (paratope)
Hinge regions

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Origen of diversity – alternative splicing

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Function of antibodies
Prevent adhesion of pathogens (bacteria and viruses)
Neutralize toxins
Opsonization of

bacteria
Complement activation

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Adaptive immune system Cellular immunity

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Cellular immunity

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Origen of variation in TCR

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How to know what happening in the cell?

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MHC with peptide

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Killer kiss

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Cancer cells can inhibit T-cells

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T-CAR