Enantioselective Total Synthesis of (+)-Vittatalactone

Retrosynthetic analysis of (+)-vittatalactone (1)

Synthesis of alcohol 4

Synthesis of (+)-vittatalactone (1)

Synthesis of (+)-vittatalactone (1)

Pinnick oxidation

A 12-membered to a strained 11-membered ring: first stereoselective total synthesis

Retrosynthesis of asteriscunolides C and D

(Ring-closing metathesis)

Synthesis of allyl alcohol fragment 11

Synthesis of acid fragment 10

A. Erkkilä and P. M. Pihko, J.

Attempted intramolecular HWE-cyclization

Yamaguchi esterification

Synthesis of clavulactone analogues 26 and 27