Содержание
- 2. General Information Epidermal Growth Factor (EGF) is a single-chain polypeptide consisting of 53 amino acids with
- 3. 1. Re-epithelialization EGF promotes epithelial cells to proliferate and move to fill wounds. 2. Promotion of
- 4. Skin Regeneration and the Healing Effect Easyef® Ointment Outstanding effect of skin generation The wound applied
- 5. Key Benefits and Features Wound healing ointment with a new concept, containing EGF, a granulation ingredient
- 6. Product Information Component In 1 g Recombinant human epidermal growth factor ------------------------------ 1 μg (Host: E.
- 8. Скачать презентацию
General Information
Epidermal Growth Factor (EGF) is a single-chain polypeptide consisting of
General Information
Epidermal Growth Factor (EGF) is a single-chain polypeptide consisting of
EGF was first isolated from the submaxillary glands of adult male mice. Human EGF was discovered in human urine as an inhibitor of gastric acid secretion. Today, hEGF has become one of the most attractive growth factors in life sciences as well as biotechnological fields.
Human EGF is a potent stimulator of epithelial and endothelial cells and fibroblast proliferation both in vitro and in vivo, which results in its potential as a promising healing agent for the treatment of various skin and corneal wounds. In dermatology, EGF can be used as a healing agent for skin wounds, such as diabetic ulcers, bed sores, venous stasis ulcers, skin burns and surgical incisions. In ophthalmology, EGF can be utilized as a healing agent for corneal ulcers and ophthalmic surgery, such as corneal transplantation and excimer laser keratectomy, and the prevention of corneal degeneration. It is also a good candidate for the treatment of gastric ulcers because it inhibits gastric acid secretion and regenerates gastric mucosal layer.
What is EGF?
Easyef® Ointment
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1. Re-epithelialization
EGF promotes epithelial cells to proliferate and move to fill
1. Re-epithelialization
EGF promotes epithelial cells to proliferate and move to fill
2. Promotion of granulation tissue
EGF stimulates fibroblasts in dermal tissue to facilitate dermal cells to differentiate and proliferate.
3. Angiogenesis
EGF promotes endothelial cells to proliferate to regenerate blood vessels.
Mechanism of EGF Action
Easyef® Ointment
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Skin Regeneration and the Healing Effect
Easyef® Ointment
Outstanding effect of skin generation
The
Skin Regeneration and the Healing Effect
Easyef® Ointment
Outstanding effect of skin generation
The
Rapid wound healing ability
The shortest healing time was achieved in the same wound area.
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1. Non-clinical study
2. Clinical study
► Indication: Wound healing (Skin graft donor site model)
► Methodology: Placebo-controlled, randomized, double-blind, multi-center study
► Primary endpoint: Healing time by the direct evaluation(naked eye) of skin graft donor site
► Result: The test group displayed statistically significant 1.0 day faster healing time
compared to the control group (p=0.0005).
1) Wilcoxon signed- rank test
Key Benefits and Features
Wound healing ointment with a new concept, containing
Key Benefits and Features
Wound healing ointment with a new concept, containing
Safe because it contains no steroids or antibiotics.
White blood cells or macrophages themselves, which are created during the healing process in our body, suppress bacteria, to some extent. Therefore, this medicine does not contain a steroid or an antibiotic of which the excessive use may make us tolerant of the antibiotic.
Proven in its safety and healing effect through a clinical studies in Korea.
Top medical staffs from three prestigious Korean Institutions (Asan Medical Center, Severance Hospital, and Samsung Medical Center) joined the clinical procedures, and approved the safety and remarkable healing effect of EGF.
Easyef® Ointment
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Table of Comparison with Competitors
Product Information
Component
In 1 g
Recombinant human epidermal growth factor ------------------------------ 1 μg
(Host:
Product Information
Component
In 1 g
Recombinant human epidermal growth factor ------------------------------ 1 μg
(Host:
Ointment base: white petrolatum (KP) ------------------------------------ 700 mg
Ointment base: Light liquid paraffin (KP) ----------------------------- 298.45 mg
Preservative: propylparaben (KP) ------------------------------------------- 1.5 mg
Appearance
Colorless or pale yellow, translucent ointment in tube
Administration/Dosage
Apply it to the infected area several times a day as needed.
Efficacy/Effect
Assistive topical treatment of wounds and skin ulcers
Storage
Store in a refrigerator (2~8℃).
Easyef® Ointment