Nucleic acids

Frederick Griffith

British physician, pathologist, bacteriologist
Known for discovery of pneumococcal transformation

Griffith’s experiment

Oswald Avery

Canadian-born American physician
 and medical and medical researcher.
The major part
of his career was spent

dСMP

The principal bases in DNA

PURINES

PYRIMIDINES

The greatest discovery!

Form of DNA

А-form В-form Z-form

Histones

H2A, H2B, H3 и H4 – similar between distant species:
-

A simple interphase organization

From Prof. de Jong lecture, 2006

Interphase loop model

H4 Acetylated euchromatin

DNA methylated heterochromatin

From Prof. de Jong lecture,

Trihybrid 1: CC x (FF x RR)

A. fistulosum -

FISH: Human chromosomes