Nephrol Dial Transplant. The emerging role of Klotho in clinical nephrology

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Nephrol Dial Transplant. Jul 2012; The emerging role of Klotho in

Nephrol Dial Transplant. Jul 2012; The emerging role of Klotho in

clinical nephrology
Ming Chang Hu, Makoto Kuro-o, Orson W. Moe
Слайд 3

Nephrology 19 (2014); The importance of klotho in phosphate metabolism and

Nephrology 19 (2014); The importance of klotho in phosphate metabolism and
kidney

disease. SVEN-JEAN TAN, EDWARD R SMITH, TIM D HEWITSON, STEPHEN G HOLT and NIGEL D TOUSSAINT
Слайд 4

Nephrology 19 (2014); The importance of klotho in phosphate metabolism and

Nephrology 19 (2014); The importance of klotho in phosphate metabolism and
kidney

disease. SVEN-JEAN TAN, EDWARD R SMITH, TIM D HEWITSON, STEPHEN G HOLT and NIGEL D TOUSSAINT
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Adv Exp Med Biol. 2012; SECRETED KLOTHO AND CHRONIC KIDNEY DISEASE

Adv Exp Med Biol. 2012;
SECRETED KLOTHO AND CHRONIC KIDNEY DISEASE
Ming

Chang Hu, Makoto Kuro-o, and Orson W. Moe
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Semin Nephrol. Mar 2013; 33(2): RENAL AND EXTRA-RENAL ACTIONS OF KLOTHO

Semin Nephrol. Mar 2013; 33(2):
RENAL AND EXTRA-RENAL ACTIONS OF KLOTHO
Ming Chang

Hu, MD, PhD, Makoto Kuro-o, MD, PhD,and Orson W. Moe, MD
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Semin Nephrol. Mar 2013; 33(2): RENAL AND EXTRA-RENAL ACTIONS OF KLOTHO

Semin Nephrol. Mar 2013; 33(2):
RENAL AND EXTRA-RENAL ACTIONS OF KLOTHO
Ming Chang

Hu, MD, PhD, Makoto Kuro-o, MD, PhD,and Orson W. Moe, MD
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Annu Rev Physiol. 2013;. Fibroblast Growth Factor 23 and Klotho: Physiology

Annu Rev Physiol. 2013;.
Fibroblast Growth Factor 23 and Klotho: Physiology and

Pathophysiology of an Endocrine Network of Mineral Metabolism
Ming Chang Hu, Kazuhiro Shiizaki, Makoto Kuro-o, and Orson W. Moe
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Contrib Nephrol. 2013; Klotho and Chronic Kidney Disease Ming Chang Hu,

Contrib Nephrol. 2013;
Klotho and Chronic Kidney Disease
Ming Chang Hu, MD,

PhD, Makoto Kuro-o, MD, PhD,1 and Orson W. Moe, MD
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Contrib Nephrol. 2013; Klotho and Chronic Kidney Disease Ming Chang Hu,

Contrib Nephrol. 2013;
Klotho and Chronic Kidney Disease
Ming Chang Hu, MD,

PhD, Makoto Kuro-o, MD, PhD,1 and Orson W. Moe, MD
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Фиброз почек Klotho действует как ингибитор факторов роста: TGF-β1, Wnt, IGF-1

Фиброз почек

Klotho действует как ингибитор факторов роста: TGF-β1, Wnt, IGF-1
TGF-β1: супрессия

MMPs, индукция TIMPs?продукция матрикса и подавление его деградации
Klotho подавляет Wnt-индуцированную транскрипцию цепей β-катенина ? ингибируется активность почечных миофибробластов, снижается отложение экстрацеллюлярного матрикса
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Nephrol Dial Transplant. Jul 2012; The emerging role of Klotho in

Nephrol Dial Transplant. Jul 2012; The emerging role of Klotho in

clinical nephrology
Ming Chang Hu, Makoto Kuro-o, Orson W. Moe