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- 2. A Therapeutic Agent and A Poison 2400 Years Ago In Greece and Rome Ancient Awareness
- 3. Quote / History (Henry Adams)….he found himself invariably taking for granted, as a political instinct, with
- 4. Quote / History They put arsenic in his meat And stared aghast to watch him eat;
- 5. For many years used to treat syphilis and amebic dysentery But caused skin cancer in patients
- 6. By product of smelting for cooper, lead, zinc Last smelter in Tacoma Washington closed in 1985
- 7. Use is dropping because of toxicity 90% used as wood preservative (although this too is being
- 8. Average 20 µg/day from food and water Background air is less than 0.1 µg/m3 Drinking water
- 9. Inorganic Arsenic Trivalent (As3+) arsenic trioxide, sodium arsenite arsenic trichloride Pentavalent (As5+) arsenic pentoxide, arsenic acid,
- 10. Organic Arsenic Less toxic that inorganic As Produced by Biomethylation Organisms in soil and water Humans
- 11. Inorganic arsenic (arsenic trioxide) 80-90% absorbed from intestine Organic arsenic (seafood) poorly absorbed from intestine Lung
- 12. Bound to red blood cells Distributes to liver Binds to sulfhydryl containing proteins - concentrates in
- 13. As5+ (Arsenate) As3+ (Arsenite) Methylarsenite (in liver) Dimethylarsenite (readily eliminated – urine) Metabolism
- 14. 3-5 days Excreted Urine (majority Skin cells Sweat HALF-LIFE
- 15. Inorganic arsenic (arsenic trioxide) 70 to 180 mg can be fatal Constriction of the throat with
- 16. Chronic exposure (drinking water) Skin cancer (recognized 100 years ago) Garlic odor on breath Excessive perspiration
- 17. Exposure Drinking water Burning arsenic treated wood Handling treated wood
- 18. US Arsenic Map
- 19. Bangladesh Arsenic Map
- 20. Children – small size, higher water consumption for size Susceptibility & Variability
- 21. Avoid (do not use treated lumber) Test drinking water Stop smoking Wash hands Reducing Exposure
- 22. Arsenic in drinking water is a worldwide human health hazard Avoid the use of arsenic treated
- 23. EPA - Drinking water 50 µg/L (50 ppb) (under review to 10 µg/L) EPA – RfD
- 24. A Small Dose of ™ Arsenic
- 25. Additional Information Web Sites ATSDR –Toxicology Profile Series Arsenic - http://www.atsdr.cdc.gov/ToxProfiles/ US Environmental Protection Agency (EPA)
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