Acute mediastinitis. Lection for students of 5 course

Содержание

Слайд 2

Acute mediastinitis is most often the result of bacterial infection of

Acute mediastinitis
is most often the result of bacterial infection
of the

mediastinum. Mediastinitis may be associated with empyema and subphrenic abscess.
Слайд 3

Causes acute mediastinitis The most common cause is oesophageal perforation. Esophageal

Causes acute mediastinitis

The most common cause is oesophageal perforation.
Esophageal perforation

may complicate esophagoscopy or insertion of a Sengstaken-Blakemore or Minnesota tube (for esophageal variceal bleeding). It may occur with vomiting (Boerhaave's syndrome). Patients with esophageal perforation are generally acutely ill, with severe chest pain and dyspnea due to mediastinal infection and inflammation
Слайд 4

Causes acute mediastinitis The other causes that are much less common

Causes acute mediastinitis

The other causes that are much less common include:


postoperative infection, particularly following median sternotomy;
leakage from the oesophagusleakage from the oesophagus into the mediastinum through a necrotic neoplasm;
traumatic rupture tracheobronchial tree;
extension of infection from adjacent anatomical regions, particularly the nasopharynx or teeth, and occasionally from adjacent structures such as the lungs, pleura, pericardium and mediastinalextension of infection from adjacent anatomical regions, particularly the nasopharynx or teeth, and occasionally from adjacent structures such as the lungs, pleura, pericardium and mediastinal lymph nodes.
Слайд 5

Symptoms patients present with chills chest pain high fever tachycardia

Symptoms

patients present with chills
chest pain
high fever
tachycardia

Слайд 6

Diagnostic Chest radiography may show mediastinalChest radiography may show mediastinal widening

Diagnostic

Chest radiography may show mediastinalChest radiography may show mediastinal widening and

findings of mediastinal abscess including gas bubbles or airfluid level.
PneumothoraxPneumothorax and pneumomediastinumPneumothorax and pneumomediastinum are frequently associated in case of oesophageal perforation.
CTCT is more sensitive than chest radiography for detecting the presence and extent of mediastinalCT is more sensitive than chest radiography for detecting the presence and extent of mediastinal fluid collections and the presence of extraluminal gas (Fig.1).
Слайд 7

Diagnostic CT scan in a patient with a mediastinal fluid collection

Diagnostic

CT scan in a patient with a mediastinal fluid collection located

within the retrosternal space. The collection is circumscribed by a rim of contrast enhancement and contains a small gas bubble (arrow). This appearance corresponded to a poststernotomy mediastinal abscess
Слайд 8

Complications of mediastinitis Abscess formation Empyema Esophagocutaneous fistulas Sternal osteomyelitis Pericardial tamponade

Complications of mediastinitis

Abscess formation
Empyema
Esophagocutaneous fistulas
Sternal osteomyelitis
Pericardial tamponade

Слайд 9

Complications of mediastinitis Common complications of mediastinitis result from extension of

Complications of mediastinitis

Common complications of mediastinitis result from extension of the

infectious process into contiguous structures and spaces.
Thus, abscess formation and empyema are relatively common complications of acute mediastinitis of any cause. Late complications of acute mediastinitis resulting from esophageal perforation include esophagocutaneous, esophagopleural, and esophagobronchial fistulas.
Sternal osteomyelitis is a common complication of mediastinitis after a cardiothoracic operation but is an infrequent complication of nonsurgical causes of mediastinitis; therefore, it would be unlikely to occur in this patient.
Слайд 10

Complications of mediastinitis Pericardial effusion and subsequent tamponade can result from

Complications of mediastinitis
Pericardial effusion and subsequent tamponade can result from direct

extension of the infectious process into the pericardial space but can also occur as a secondary inflammatory response to infection. The incidences of pericardial effusion, abscess, and empyema formation all increase if treatment is delayed.
Soon after admission of this patient, clinical signs of tamponade developed, including a pulsus paradoxus, worsening dyspnea, and increased jugular venous pressure.
Слайд 11

Complications of mediastinitis diagnostic Echocardiography demonstrated a moderate to large circumferential

Complications of mediastinitis diagnostic

Echocardiography demonstrated a moderate to large circumferential pericardial

effusion.
Pericardiocentesis was subsequently performed; 500 mL of serous fluid was drained, and a percutaneous pigtail catheter was placed for continued drainage.
The patient also underwent thoracentesis for diagnostic and therapeutic purposes.
Слайд 12

Complications of mediastinitis diagnostic Laboratory analysis of the recovered fluid revealed

Complications of mediastinitis diagnostic

Laboratory analysis of the recovered fluid revealed pericardial and

pleural exudates, with total nucleated cell counts of 2.55×109/L (91% neutrophils) and 6.9×109/L (81% neutrophils), respectively. Gram stain, fungal and acid-fast stains, and cultures of the recovered fluid were negative.
Слайд 13

Treatment open surgical drainage and débridement are necessary to prevent serious

Treatment

open surgical drainage and débridement are necessary to prevent serious morbidity

and mortality. The importance of early diagnosis and surgical management has been clearly documented. Delay in treatment can result in extensive local advancement within as short a time span as 12 hours and is associated with a steep increase in mortality.
The antibiotic treatment in this patient was sufficiently broad to cover organisms commonly implicated in acute mediastinitis but was unable to curtail the rapid progression of the infection.
Слайд 14

Treatment Percutaneous catheter drainage has been used in less urgent clinical

Treatment

Percutaneous catheter drainage has been used in less urgent clinical settings,

often as a temporizing measure, but open surgical drainage remains the standard of therapy. Although the initial Gastrografin swallow study failed to document an esophageal perforation, the working hypothesis was that a small perforation during the patient’s recent EGD led to the patient’s subsequent mediastinal infection. Because of the deteriorating clinical situation, observation or repeated attempts to document an esophageal perforation would be of no value.
Слайд 15

Treatment The patient underwent an open thoracotomy with drainage and removal

Treatment

The patient underwent an open thoracotomy with drainage and removal of

right paratracheal and subcarinal abscesses, aggressive irrigation, and pericardiotomy. Bronchoscopy and rigid esophagoscopy done at the initiation of the procedure demonstrated no visible fistulas or other abnormalities. Thoracotomy disclosed a large mediastinal mass superior to the azygos vein and a second large mass in the subcarinal space.