Protein and amino acid metabolism

Сентябрь 9, 2022

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Protein and amino acid metabolism

Содержание

2. Protein-rich products
3. Essential amino acids valine, leucine, isoleucine, lysine, methionine, threonine, tryptophan, phenylalanine Semiessential amino acids arginine and
4. Proteases Serine proteases Cysteine proteases Aspartic proteases Metalloproteases Treonine proteases Glutamic proteases
5. Active site of tripsin Active site of chymotripsin
6. HCL secretion
7. Pepsinogen activation
8. The selectivity of pepsin
9. Trypsinogen activation
10. Activation of intestinal proteases
11. The selectivity of peptidases
12. Amino acid absorption
13. Transport Catalytic cycle of GGT
14. Conversion of amino acids under the action of intestinal microflora
15. Proteolysis in tissues
16. Avram Hershko, Aaron Ciechanover and Irwin Rose Nobel Prize in Chemistry, 2004
17. Reactions of amino group Reductive deamination Hydrolytic deamination Intramolecular deamination urocanic acid histidine
18. Oxidative deamination
19. Transamination
20. Evaluation of transaminase activity Alanine + α-ketoglutarate → → pyruvate + glutamate AST ALT
21. Transaminases in human tissues (U/g protein)
22. de Ritis ratio АSТ АLТ = Myocardial infarction DRr > 1,3 Viral hepatitis DRr
23. Decarboxylation
24. thiamine pyrophosphate
25. Decarboxylation glutamic acid γ-aminobutyric acid
26. Oxidative deamination of biogenic amines R-CH2-NH2 + E-FAD + H2O → R-CHO + NH3 + E-FAD⋅H2
27. Ammonia neutrralisation
28. Urea cycle. Reactions 1, 2 NH3 + CO2 +2 ATP + H2O → H2N-CO-OPO3H2 + 2
29. Urea cycle. Reaction 3 Argininosuccinate synthetase
30. Urea cycle. Reaction 4 Argininosuccinase
31. Urea cycle. Reaction 5 Rate-limiting!
33. Kwashiorkor
36. Скачать презентацию

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Protein-rich products

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Essential amino acids
valine, leucine, isoleucine, lysine, methionine, threonine, tryptophan,

phenylalanine

Semiessential amino acids

arginine and histidine

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Proteases
Serine proteases
Cysteine proteases
Aspartic proteases
Metalloproteases
Treonine proteases
Glutamic proteases

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Active site of tripsin
Active site of chymotripsin

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HCL secretion

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Pepsinogen activation

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The selectivity of pepsin

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Trypsinogen activation

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Activation of intestinal proteases

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The selectivity of peptidases

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Amino acid absorption

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Transport Catalytic cycle of GGT

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Conversion of amino acids under the action of intestinal microflora

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Proteolysis in tissues

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Avram Hershko,
Aaron Ciechanover and Irwin Rose
Nobel Prize in Chemistry, 2004

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Reactions of amino group
Reductive deamination
Hydrolytic deamination
Intramolecular deamination
urocanic acid
histidine

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Oxidative deamination

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Transamination

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Evaluation of transaminase activity
Alanine + α-ketoglutarate →
→ pyruvate + glutamate
AST
ALT

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Transaminases in human tissues (U/g protein)

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de Ritis ratio
АSТ
АLТ
=
Myocardial infarction DRr > 1,3
Viral hepatitis DRr < 1

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Decarboxylation

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thiamine pyrophosphate

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Decarboxylation
glutamic acid
γ-aminobutyric acid

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Oxidative deamination of biogenic amines
R-CH2-NH2 + E-FAD + H2O →
R-CHO + NH3 +

E-FAD⋅H2
E-FAD⋅H2 + O2 → E-FADH2 + H2O2

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Ammonia neutrralisation

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Urea cycle. Reactions 1, 2
NH3 + CO2 +2 ATP +

H2O
→ H2N-CO-OPO3H2 + 2 ADP + H3PO4

Carbamoylphosphate
synthetase

Ornithine transcarbamoilase

Rate-limiting!

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Urea cycle. Reaction 3
Argininosuccinate
synthetase

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Urea cycle. Reaction 4
Argininosuccinase

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Urea cycle. Reaction 5
Rate-limiting!

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Kwashiorkor

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