Neuroimaging diagnosis in neurodegenerative diseases

Июль 31, 2022

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Neuroimaging diagnosis in neurodegenerative diseases

Содержание

2. INTRODUCTION Despite the fact that extensive progress in neuroimaging techniques of the brain has been made,
3. PARKINSON’S DISEASE a degenerative and progressive disorder of the central nervous system - Motor -tremor(resting) -muscle
4. NEUROIMAGING -Cranial computed tomography (cranial CT) -Magnetic resonance imaging (MRI) -Positron emission tomography (PET) -Single photon
5. POSITRON EMISSION TOMOGRAPHY (PET) -the highest sensitivity -changes in regional cerebral blood flow glucose, oxygen, dopa
6. IMAGING detecting changes in brain structure (structural imaging) examining regional changes in brain metabolism and receptor
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Слайд 2

INTRODUCTION
Despite the fact that extensive progress in neuroimaging techniques of the brain

has been made, there is no specific pattern of pathological changes in any type of dementia.

Слайд 3

PARKINSON’S DISEASE
a degenerative and progressive disorder of the central nervous system -
Motor
-tremor(resting)
-muscle

rigidity
-postural instability with problems with coordination
-slowness of movements -bradykinesia
-loss of physical movement

Non-motor

-high-level cognitive dysfunction
-psychiatric and emotional changes -depression
-difficulty in swallowing and speaking
-sensory symptoms -constipation and/or urinary problems

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NEUROIMAGING
-Cranial computed tomography (cranial CT)
-Magnetic resonance imaging (MRI)
-Positron emission tomography (PET)
-Single

photon emission tomography (SPECT)

Слайд 5

POSITRON EMISSION TOMOGRAPHY (PET)

-the highest sensitivity
-changes in regional cerebral blood

flow glucose, oxygen, dopa metabolism, and brain receptor binding
-to detect femtomolar levels of positron-emitting radioisotopes at a spatial resolution of 3–5 mm and corrects for scatter Single photon emission tomography (SPECT)
-lower sensitivity
-is unable to correct for scatter

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IMAGING

detecting changes in brain structure (structural imaging)
examining regional changes in

brain metabolism and receptor binding associated with disorder

Functional neuroimaging of nigrostriatal dopaminergic pathways is an important method for the evaluation the dopaminergic terminals in the striatum. For evaluating of the dopaminergic terminals we use radiligands with both PET and SPECT.

Neuroimaging diagnosis in neurodegenerative diseases

Содержание

INTRODUCTIONDespite the fact that extensive progress in neuroimaging techniques of the brain

PARKINSON’S DISEASEa degenerative and progressive disorder of the central nervous system -Motor-tremor(resting)-muscle

NEUROIMAGING-Cranial computed tomography (cranial CT)-Magnetic resonance imaging (MRI)-Positron emission tomography (PET)-Single

POSITRON EMISSION TOMOGRAPHY (PET) -the highest sensitivity-changes in regional cerebral blood

IMAGING detecting changes in brain structure (structural imaging) examining regional changes in

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INTRODUCTION
Despite the fact that extensive progress in neuroimaging techniques of the brain

PARKINSON’S DISEASE
a degenerative and progressive disorder of the central nervous system -
Motor
-tremor(resting)
-muscle

NEUROIMAGING
-Cranial computed tomography (cranial CT)
-Magnetic resonance imaging (MRI)
-Positron emission tomography (PET)
-Single

POSITRON EMISSION TOMOGRAPHY (PET)

-the highest sensitivity
-changes in regional cerebral blood

IMAGING

detecting changes in brain structure (structural imaging)
examining regional changes in