Содержание
- 2. Tissue Repair may start early after tissue damage regeneration by parenchymal cells of the same type
- 3. Regeneration and Reparation regeneration restoration of normal structure and function persistence of supportive „tissue skeleton“ necessary
- 4. Tissue types permanent nonproliferative in postnatal life neurons (?), cardiomyocytes (?) stable regeneration as response to
- 5. Cell-ECM interactions not only cells! EMC plays important role in healing interstitial matrix – by fibroblasts
- 6. Cell-ECM interactions ECM function mechanical support determination of cell polarity control of cell growth maintenance of
- 7. Replacement of necrotic tissue resorption by macrophages dissolution by enzymes replacement by granulation tissue uniform mechanism
- 8. Granulation tissue new-formed connective tissue, apparent from 3rd day thin-walled capillary vessels fibroblasts loose extracellular matrix
- 9. Granulation tissue pink soft granular appearance richly vascularized highly cellular myxoid matrix inflammatory cells e.g. surface
- 10. Angiogenesis neovascularization x vasculogenesis (embryonic process only) highly complex phenomenon angiogenic factors (FGF, VEGF) antiangiogenic factors
- 11. Fibrosis and Remodeling scar formation fibroblasts myofibroblasts spindle cells of both fibroblastic and smooth muscle phenotype
- 12. Fibrosis and Remodeling abundant collagen fibres bridging the defect devoid of inflammatory cells reepithelization of surface
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