Neurodevelopmental disorders

Содержание

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Outline Overview of Neurodevelopmental Disorders Attention Deficit/Hyperactivity Disorder Specific Learning Disorder

Outline

Overview of Neurodevelopmental Disorders
Attention Deficit/Hyperactivity Disorder
Specific Learning Disorder
Autism Spectrum Disorder
Intellectual Disability

(Intellectual Development Disorder)
Prevention of Neurodevelopmental Disorders
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Focus Questions What are the defining features of ADHD? What is

Focus Questions

What are the defining features of ADHD?
What is a specific

learning disorder?
What are the major features of autism spectrum disorders?
How is intellectual disability defined?
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Neurodevelopmental Disorders Diagnosed first in infancy, childhood, or adolescence Include the

Neurodevelopmental Disorders

Diagnosed first in infancy, childhood, or adolescence
Include the following:
Attention deficit

hyperactivity disorder (ADHD)
Specific learning disorder
Autism spectrum disorder
Intellectual Disability
Communication and Motor Disorders
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Nature of Developmental Psychopathology: An Overview Normal vs. abnormal development Consider

Nature of Developmental Psychopathology: An Overview

Normal vs. abnormal development
Consider age and

environment of child
Developmental psychopathology
Study of how disorders arise and change with time
Disruption of early skills can affect later development
Caution: do not excessively pathologize childhood behavior that is part of normal development
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Stuttering Cluttering -rapid and/or irregular speech rate causative gene mutations linked to stuttering

Stuttering Cluttering -rapid and/or irregular speech rate
causative gene mutations linked to

stuttering
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Attention Deficit/Hyperactivity Disorder (ADHD) Nature of ADHD Central features – inattention,

Attention Deficit/Hyperactivity Disorder (ADHD)

Nature of ADHD
Central features – inattention, overactivity, and impulsivity
Associated

with numerous impairments
Behavioral
Cognitive
Social and academic problems
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Types of Attention Deficit Hyperactivity Disorder Subtypes(ADHD) Inattentive Hyperactive/impulsive Combined

Types of Attention Deficit Hyperactivity Disorder Subtypes(ADHD)

Inattentive
Hyperactive/impulsive
Combined

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ADHD: Facts and Statistics Prevalence Occurs in approximately 5% of school-aged

ADHD: Facts and Statistics

Prevalence
Occurs in approximately 5% of school-aged children

throughout the world
ADHD most commonly diagnosed in the United States, although prevalence appears fairly constant worldwide
One study: 11% of children aged 4 to 17 were labeled with ADHD in 2011-2012
In general population (including adults), 5 to 9% meet criteria
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Test ADHD The 'Unofficial' ADHD Test for Adults https://youtu.be/iozAFIr3BEw till 12min 24 Test https://totallyadd.com/do-i-have-add/

Test ADHD

The 'Unofficial' ADHD Test for Adults https://youtu.be/iozAFIr3BEw till 12min 24
Test

https://totallyadd.com/do-i-have-add/
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ADHD: Facts and Statistics, Continued Course of ADHD Symptoms usually appear

ADHD: Facts and Statistics, Continued

Course of ADHD
Symptoms usually appear around age

3 to 4
Half of children with ADHD continue to have difficulties as adults
Divorce, lower education, substance use
Impulsivity decreases, but inattention remains
Gender differences: Boys outnumber girls 3:1
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Causes of ADHD: Biological Contributions Genetic contributions ADHD seems to run

Causes of ADHD: Biological Contributions

Genetic contributions
ADHD seems to run in

families
Partially explained by copy number variants – extra or missing copies of genes on chromosome
The role of toxins
Food additives (e.g., dyes, pesticides) may play very small role in hyperactive/impulsive behavior among children
Maternal smoking increases risk
Neurobiological correlates of ADHD
Inactivity of the frontal cortex and basal ganglia
Abnormal frontal lobe development, poor inhibitory control
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Causes of ADHD: Psychosocial Contributions Psychosocial factors ADHD children are often

Causes of ADHD: Psychosocial Contributions

Psychosocial factors
ADHD children are often viewed negatively

by others > Frequent negative feedback from peers and adults
Peer rejection and resulting social isolation
Such factors foster low self-esteem
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Treatment of ADHD Goal of biological treatments: reduce impulsivity and hyperactivity,

Treatment of ADHD

Goal of biological treatments: reduce impulsivity and hyperactivity, improve

attention
Behavioral treatment for children
Reinforcement programs increase appropriate behaviors, decrease inappropriate behaviors
May also involve parent training
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Надо какое ниб упражнение

Надо какое ниб упражнение

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Specific Learning Disorders: An Overview Scope of learning disorders Academic problems

Specific Learning Disorders: An Overview

Scope of learning disorders
Academic problems in

reading, mathematics, and/or writing
Performance substantially below expected levels based on age and/or demonstrated capacity
Problems persist for 6+ months despite targeted intervention
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Specific Learning Disorder: Types With impairment in reading, may include: Word

Specific Learning Disorder: Types

With impairment in reading, may include:
Word reading accuracy
Reading

rate or fluency
Reading comprehension
With impairment in written expression, may include:
Spelling accuracy
Grammar punctuation and accuracy
Clarity/organization of written expression
With impairment in mathematics, may include:
Number sense
Memorization of arithmetic facts
Accurate or fluent calculation
Accurate math reasoning
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Specific Learning Disorder: Statistics Prevalence of learning disorders 5 to 15%

Specific Learning Disorder: Statistics

Prevalence of learning disorders
5 to 15% prevalence across

youth of various age and cultures
Highest rate of diagnosis in wealthier regions, but children with low SES more likely to have difficulties
Reading difficulties most common, affect 7% of the general population
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Specific Learning Disorders: Statistics, Continued Students with learning disorders are more

Specific Learning Disorders: Statistics, Continued

Students with learning disorders are more likely

to:
Drop out of school
Be unemployed
Have suicidal thoughts
Have negative school experiences
May be related to communication disorders
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Causes of Specific Learning Disorder Genetic and neurobiological contributions Learning disorders

Causes of Specific Learning Disorder

Genetic and neurobiological contributions
Learning disorders run in

families, but specific difficulties are not inherited
Evidence for subtle neurological difficulties is mounting (e.g., decreased functioning of areas responsible for word recognition)
Overall, contributions are unclear
Performance also influenced by:
Motivational factors
Socioeconomic status
Cultural expectations
Parental interactions
Child management practices
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Neurological Differences in Dyslexia

Neurological Differences in Dyslexia

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Treatment of Specific Learning Disorder Requires intense educational interventions Remediation of

Treatment of Specific Learning Disorder

Requires intense educational interventions
Remediation of basic processing

problems, cognitive skills, and compensatory skills
Examples:
Vocabulary, discerning meaning, fact finding, decision making, critical thinking
Data support behavioral educational interventions
Biological interventions (e.g., Ritalin) usually used only for those individuals who also have ADHD
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Autism Spectrum Disorder Problems occur in language, socialization, and cognition Pervasive

Autism Spectrum Disorder

Problems occur in language, socialization, and cognition
Pervasive – problems

span many life areas
25% don’t acquire effective speech
Restricted, repetitive patterns of behavior, interests, or activities
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Autism Spectrum Disorder Label is new to DSM-5 Encompasses several disorders

Autism Spectrum Disorder

Label is new to DSM-5
Encompasses several disorders previously classified

as “pervasive developmental disorders”
Including:
Autistic disorder
Asperger’s disorder
Childhood disintegrative disorder
Rett syndrome
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Rett Syndrom

Rett Syndrom

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Impairment in Social Communication and Interaction Defining characteristic: Failure to develop

Impairment in Social Communication and Interaction

Defining characteristic: Failure to develop

age-appropriate social relationships
Trouble initiating and maintaining relationships
Trouble with nonverbal communication
May lack appropriate expressions, tone
Trouble with social reciprocity
Deficits in joint attention – the ability to communicate interest in an external stimulus and another person at the same time
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What Autism Looks Like [INSERT Photo, p. 526 HERE]

What Autism Looks Like
[INSERT Photo, p. 526 HERE]

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Restricted or Repetitive Behaviors and Interests Preference for the status quo

Restricted or Repetitive Behaviors and Interests

Preference for the status quo –

maintenance of sameness
Severe forms: Stereotyped or ritualistic behavior
E.g., spinning, waving hands, rocking
Less severe forms: Intense, circumscribed interest in very specific subjects
Having restricted areas of interest may compound difficulties relating to others
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Autism Spectrum Disorder: Prevalence Previously thought to be very rare, but

Autism Spectrum Disorder: Prevalence

Previously thought to be very rare, but

this is not the case
1 in 50 school-aged children meet criteria
More commonly diagnosed in males
Gender ratio: 4 to 5:1
IQ interaction
38% show intellectual disabilities
Occurs worldwide
The better the language skills and IQ test performance, the better the prognosis
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Psychological and Social Dimensions Historical views Failed parenting Perfectionistic, cold, and

Psychological and Social Dimensions

Historical views
Failed parenting
Perfectionistic, cold, and aloof
Parents thought

to have high socioeconomic status and higher IQs
This view is not currently supportive
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Biological Dimensions Significant genetic component Familial component: If you have one

Biological Dimensions

Significant genetic component
Familial component: If you have one child with

autism, the chance of having a second child with autism is 20% (100x greater risk than general population)
Numerous genes on several chromosomes involved
Older parents associated with increased risk
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Neurobiological Influences Neurobiological influences Amygdala Larger size at birth = higher

Neurobiological Influences

Neurobiological influences
Amygdala
Larger size at birth = higher anxiety, fear
Elevated cortisol
Neuronal

damage in the amygdala results from high stress, which may affect processing of social situations
Oxytocin
Lower levels in individuals with ASD
giving oxytocin to people with ASD improved their ability to remember and process infor- mation with emotion content
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Vaccination Risks Highly controversial theory is that mercury Vaccinations do NOT

Vaccination Risks

Highly controversial theory is that mercury
Vaccinations do NOT increase the

risk of autism
Mercury in some vaccinations was rumored to increase autism risk
Large scale studies do NOT support this
High rates of vaccinations do NOT increase risk for autism in the community at large
Health risk of not vaccinating is substantial
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Scientists discover how a gene mutation causes autism Children with autism

Scientists discover how a gene mutation causes autism

Children with autism 'have

too many synapses in their brain'

Mutations in a gene called UBE3A cause it to become hyperactive, leading to abnormal brain development and autism/ This hyperactivity causes autism
While the parents of the children had no UBE3A mutations, the children did. The UBE3A gene in the children was permanently switched on. Children and adolescents with autism have too many synapses in their brain, which can affect their brain function
Mutated UBE3A gene to mouse models the development of dendritic spines on the brain cells -too many dendritic spines has been associated with autism
Children with autism 'have too many synapses in their brain
In the brains of individuals without autism, the number of spines had reduced by almost 50% by late childhood. However, the number of spines in the brains of those with autism had only reduced by 16% by late childhood.

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Treatment of Autism Spectrum Disorder Psychosocial treatments Behavioral approaches Skill building

Treatment of Autism Spectrum Disorder

Psychosocial treatments
Behavioral approaches
Skill building
Reduce problem behaviors
Communication and

language training
Increase socialization
Naturalistic teaching strategies
Early intervention is critical – may “normalize” the functioning of the developing brain
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Treatment of Autism Spectrum Disorder, Continued Biological treatments Medical intervention has

Treatment of Autism Spectrum Disorder, Continued

Biological treatments
Medical intervention has had little

positive impact on core dysfunction
Some drugs decrease agitation
Tranquilizers
SSRIs
Indicators of good prognosis
High IQ, good language ability
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Treatment of Autism Spectrum Disorder, Part 3 Integrated treatments Preferred model:

Treatment of Autism Spectrum Disorder, Part 3

Integrated treatments
Preferred model: Multidimensional, comprehensive

focus
Children offered special education at school focusing on communication
Judicious use of medication in some cases
Families given support too
When older, focus on integrating into the community while maximizing independence
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Intellectual Disability (Intellectual Development Disorder) Overview Below-average intellectual and adaptive functioning

Intellectual Disability (Intellectual Development Disorder)

Overview
Below-average intellectual and adaptive functioning
First evident

in childhood
Range of impairment varies greatly
Previously called mental retardation
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Intellectual Disability IQ typically below 70 to 75 Previously distinguished different

Intellectual Disability

IQ typically below 70 to 75
Previously distinguished different levels of

severity; IQ may be as low as under 20
Previously diagnosed on DSM-IV Axis II
Reserved for conditions that 1) are chronic and pervasive and 2) are likely to influence the presentation of other mental disorders
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Levels of Intellectual Disability Mild IQ = 50 or 55 to

Levels of Intellectual Disability

Mild
IQ = 50 or 55 to 70
Moderate
IQ =

35-40 to 50-55
Severe
IQs = 20-25 to 35-40
Profound
IQ = below 20 to 25
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Intellectual Disability, DSM-5 DSM-5 identifies difficulties in three domains Conceptual (e.g.,

Intellectual Disability, DSM-5

DSM-5 identifies difficulties in three domains
Conceptual (e.g., skill deficits

in areas such as language, reasoning, knowledge, and memory)
Social (e.g., problems with social judgment and the ability to make and retain friendships)
Practical (e.g., difficulties managing personal care or job responsibilities)
Devalued by society
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Other Classification Systems for Intellectual Disability American Association of Intellectual and

Other Classification Systems for Intellectual Disability

American Association of Intellectual and Developmental

Disabilities (AAIDD)
Based on assistance required
Intermittent
Limited
Extensive
Pervasive
Keeps the emphasis on what assistance is needed
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Intellectual Disability: Statistics Prevalence = 1 to 3% of general population

Intellectual Disability: Statistics

Prevalence = 1 to 3% of general population
9 in

10 people with ID have mild impairment (IQ 50 to 70)
Chronic course
Highly variable individual prognosis
Independence is possible for many individuals with mild impairment when provided with appropriate resources (e.g., skills training)
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Causes of Intellectual Disability Hundreds of known causes Environmental (e.g., neglect)

Causes of Intellectual Disability

Hundreds of known causes
Environmental (e.g., neglect)
Prenatal (e.g., exposures

to toxins in the womb)
Perinatal (e.g., problems with delivery)
Postnatal (e.g., head injury)
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Examples of Causes of Intellectual Disability Examples Fetal alcohol syndrome Exposure

Examples of Causes of Intellectual Disability

Examples
Fetal alcohol syndrome
Exposure to other illness

in the womb
Lack of oxygen (anoxia) during birth
Malnutrition
Head injuries
Childhood abuse
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Causes of Intellectual Disability: Genetics Genetic influences Chromosomal disorders (e.g., Down

Causes of Intellectual Disability: Genetics

Genetic influences
Chromosomal disorders (e.g., Down Syndrome)
Multiple genetic

mutations
Single genes can be responsible
Dominant genes less often responsible for ID (because people with ID are less likely to have children)
Recessive genes more often responsible
As many as 30% cases of ID have no identified etiology
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Lesch-Nyham syndrome Genetic influences: De novo disorders (= mutation occurring in

Lesch-Nyham syndrome

Genetic influences: De novo disorders (= mutation occurring in the

sperm or egg or after fertilization)
Intellectual disability, symptoms of cerebral palsy, self-injurious behavior
Recessive allele on the X chromosome > only affects males (females have an additional X chromosome to balance)
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Phenylketonuria (PKU) Treatment at any time during pregnancy may reduce the

Phenylketonuria (PKU)

Treatment at any time during pregnancy may reduce the severity

of developmental delay. 

The most common inborn error of amino acid metabolism.
Sources of phenylalanine are eggs, chicken, liver, beef, milk, and soybeans

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Causes of Intellectual Disability: Down Syndrome Chromosomal influences Down Syndrome Most

Causes of Intellectual Disability: Down Syndrome

Chromosomal influences
Down Syndrome
Most common chromosomal

cause of intellectual disability
Extra 21st chromosome (Trisomy 21)
Distinctive physical symptoms
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Causes of Intellectual Disability: Down Syndome, Continued Down Syndrome Higher risk

Causes of Intellectual Disability: Down Syndome, Continued

Down Syndrome
Higher risk with advanced

maternal age
Detectable with some prenatal tests
Amniocentesis
Chorionic villus sampling (CVS)
Mother’s blood tests
Tests do not indicate severity of impairment
1 in 4 mothers elects to terminate the pregnancy
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Causes of Intellectual Disability: Fragile X Syndrome Fragile X syndrome Symptoms

Causes of Intellectual Disability: Fragile X Syndrome

Fragile X syndrome
Symptoms
Learning disabilities
Hyperactivity
Short attention

span
Gaze avoidance
Perseverative speech
Gender differences
Primarily affects males
Women with Fragile X have mild symptoms
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Causes of Intellectual Disability: Cultural-Familial Intellectual Disability Cultural-familial intellectual disability: Refers

Causes of Intellectual Disability: Cultural-Familial Intellectual Disability

Cultural-familial intellectual disability: Refers to

intellectual disability influenced by social environmental factors, such as:
Abuse
Neglect
Social deprivation
These factors likely interact with existing biological factors
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Treatment of Intellectual Disability Severe ID: Treatment similar to that for

Treatment of Intellectual Disability

Severe ID: Treatment similar to that for autism

spectrum disorder
Mild ID: Treatment similar to that for learning disorders
Goals are similar across severity; level of assistance differs
Behavioral interventions teach:
Basic skills (e.g., dressing, hygiene)
Social skills
Practical skills (e.g., paying bills)
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Treatment of Intellectual Disability: Goals Common goals Participate in community life

Treatment of Intellectual Disability: Goals

Common goals
Participate in community life
Benefit from education
Hold

a job or other productive pursuits (e.g., volunteering)
Build meaningful relationships
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Prevention of Neurodevelopmental Disorders Efforts are still in early stages Early

Prevention of Neurodevelopmental Disorders

Efforts are still in early stages
Early interventions for

at-risk children
Head Start Program: Educational, medical (e.g., nutritional), and social support
Future directions: Genetic screening
Detection and correction
Prenatal gene therapy