Содержание
- 2. Plague (pestis, black death) Identification: the acutest, naturally-focal, trans-missible disease characterized by: high fever, exitation, septicemia
- 3. Ancient illness animal and man: - The VIth сentury of AD - «Justinian the plague »
- 4. ETIOLOGY Y. pestis ( F. Enterobacteriaceae. K. Yersinia) – this is oval rod by a size
- 7. Pleomorphism is very common in this species and in old cultures, involution forms are seen :
- 8. At warming up to 70 d.C perish in 10 minutes and at boiling in 1 minute.
- 9. the coagulase- promotes forms of thrombuses with subsequent by violation of microcirculation in tissues - mouse’s
- 10. - the hemolysin - intensifys a hemolysis of erythrocytes - bacteriolysins: pesticin 1 and pesticin 2-
- 11. Epidprocess among rodents proceeds as enzootic or epizootic. At enzootic - the agent permanently circulates among
- 12. In urban the sources (synonyms- port’s, rat’s, ship’s plague) the main role belongs rats: grey, black,
- 13. The plague can be transmitted and other ways: - contact way – at taking of hides
- 21. The patient with the pulmonary form represent most danger for the surroundings. The patients with the
- 22. PATHOGENY and PATHOMORPHOLOGY Yersinias after penetrated through a skin or mucous in the lymphatic system of
- 23. 4. At aerogenic infection the primary pneumonia with subsequent the hematosepsis and death of the patient
- 24. CLINIC The incubation interval at a bubonic plague from 2 to 6 days, at the pneumonic
- 25. CLINICAL MANIFESTATION
- 26. The dermal form in a place of implantation occurs a hyperemia and infiltration, which fast passes
- 30. The bubonic form - starts acutely, without a prodrome. - chill and fast rise of temperature
- 31. Features of buboes at a plague: - the damage of lymph nodi starts with pain, without
- 32. - the buboes of the 2nd and the 3rd order proceed without a periadenitis - in
- 36. The pneumonic form of a plague Differs by extremely rapid current but the signs of a
- 37. - tachypnea it is revealed for all patients and always not matches to an expressiveness of
- 38. - More often proceeds as pleuropneumonias with strong by pains in a thorax, is especial at
- 41. The septic form of a plague - initially develops only for 1- 3 % of cases,
- 42. Differential diagnosis: The dermal form (antrax, tularemia, malleus) The bubonic form (purulent lymphadenitis, tularemia, lymphogranulomatos, lymphoreticulosis)
- 43. Differential diagnostics with a tularemia: The dermal form - a minimum intoxication, sluggish creation of a
- 44. Francisella tularensis bacteria stained with methylene blue
- 45. Thumb with skin ulcer of tularemia.
- 46. Typical ulcer at tularemia
- 47. Typical ulcer at tularemia on an extremity Courtesy of Dr Hon http://www.emedicine.com/derm/topic905.htm
- 48. Ulceroglandular tularemia on the face. Courtesy of Dr Hon Pak. http://www.emedicine.com/derm/topic905.htm
- 49. tularemia ( axillary bubo)
- 50. LABORATORY DIAGNOSIS Microscopic the method plays the important role in express diagnosis – detection Gram (-)
- 51. - The accelerated biological test (intraperitoneal infection together with glucocorticoids and egg protein) - is especially
- 52. - Gentavicin - 2 – 2.5 mg/kg IM bid - Doxycycline – 1.5 mg/kg PO bid
- 53. Conditions of a discharge from hospitals: At the bubonic form - complete convalescence + two negative
- 54. Antiepidemic measures in the center of a plague: The information about falling sick or suspicious transmitted
- 55. ТУЛЯРЕМИЯ ( TULAREMIA ) Острое инфекционное природно-очаговое заболевание с поражением лимфатических узлов, кожных покровов, иногда глаз,
- 56. TULAREMIA Acute infectious naturally-focal disease with a lesion of lymphatic system, dermal integuments, sometimes of eyes,
- 57. Francisella tularensis bacteria stained with methylene blue
- 58. ЭПИДЕМИОЛОГИЯ Туляремия – распространенное природно-очаговое заболевание умеренного климатического пояса Северного полушария. Типы очагов – лесной, степной,
- 59. EPIDEMIOLOGY Tularemia – propagated naturally-focal disease of a moderate climatic girdle of Northern hemisphere. Phylums of
- 60. PATHOGENY Bacteria penetrate through a skin, mucosas of eyes, respiratory tracts, GASTROINTESTINAL TRACT. At a puncture
- 61. ПАТОГЕНЕЗ Бактерии проникают через кожу, слизистые оболочки глаз, дыхательных путей, ЖКТ. При укусе насекомых-часто развивается первичный
- 62. КЛИНИКА Инкубационный период 3- 7 дней ( от 1 до 30 дней). Выделяют следующие формы туляремии:
- 63. Относительная брадикардия, гипотония, гепатосплено-мегалия. ОАК- умеренный лейкоцитоз с нейтрофилией со сменой в дальнейшем на лимфомоноцитоз. СОЭ
- 64. Подмышечный бубон при туляремии
- 65. 2.Язвенно- бубонная чаще при трансмиссивном заражении В месте внедрения появляется пятно, папула, везикула, пустула, неглубокая язва
- 66. The typical ulcer of tularemia
- 67. Thumb with skin ulcer of tularemia.
- 68. Ulceroglandular tularemia on an extremity Courtesy of Dr Hon http://www.emedicine.com/derm/topic905.htm
- 69. Ulceroglandular tularemia on the face. Courtesy of Dr Hon Pak. http://www.emedicine.com/derm/topic905.htm
- 70. 5. Абдоминальная – поражение мезентериальных лимфоузлов Сильные боли в мезогастрии, тошнота, рвота, анорексия, иногда диарея и
- 71. Головная боль, ознобы, миалгия, слабость. Возможны спутан-ность сознания, бред, галлюцинации. Тоны сердца глухие, пульс лабилен, низкое
- 72. ЛЕЧЕНИЕ Антиинфекционная терапия ( доза – от тяжести) –Streptomycin - 15-20 mg/kg/day IM в 2 приема
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