Содержание
- 2. Gerhard Domagk Gerhard Johannes Paul Domagk (30 October 1895 – 24 April 1964) was a German
- 3. Biography Education Domagk was born in Lagow, Brandenburg, the son of a school headmaster. Until he
- 4. Career In 1925, he followed his professor Walter Gross to the University of Münster (WWU) and
- 5. In 1939, Domagk received the Nobel Prize in Medicine for this discovery, the first drug effective
- 6. contribution to medicine Domagk earned a medical degree from the University of Kiel in 1921. He
- 7. He noticed the antibacterial action of one of the dyes against streptococcal infection in mice. The
- 9. Скачать презентацию
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Gerhard Domagk
Gerhard Johannes Paul Domagk
(30 October 1895 – 24 April 1964)
Gerhard Domagk
Gerhard Johannes Paul Domagk
(30 October 1895 – 24 April 1964)
was a German pathologist and bacteriologist.
He is credited with the discovery of Sulfonamidochrysoidine (KI-730), the first commercially available antibiotic and marketed under the brand name Prontosil, for which he received the 1939 Nobel Prize in Physiology or Medicine
He is credited with the discovery of Sulfonamidochrysoidine (KI-730), the first commercially available antibiotic and marketed under the brand name Prontosil, for which he received the 1939 Nobel Prize in Physiology or Medicine
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Biography
Education
Domagk was born in Lagow, Brandenburg, the son of a school
Biography
Education
Domagk was born in Lagow, Brandenburg, the son of a school
headmaster. Until he was 14, he attended school in Sommerfeld (now Lubsko, Poland). Domagk studied medicine at the University of Kiel, but volunteered to serve as a soldier in World War I, where he was wounded in December 1914, working the rest of the war as a medic. After the war, he finished his studies, and worked at the University of Greifswald, where he researched infections caused by bacteria.
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Career
In 1925, he followed his professor Walter Gross to the University of
Career
In 1925, he followed his professor Walter Gross to the University of
Münster (WWU) and became a professor there himself. He also started working at the Bayer laboratories at Wuppertal. The same year, he married Gertrud Strube (1897–1985). Later they would have three sons and a daughter.
Domagk was appointed director of Bayer's Institute of Pathology and Bacteriology, where he continued the studies of Josef Klarer and Fritz Mietzsch, based on works by Paul Ehrlich, to use dyes, at that time a major product of IG Farben, as antibiotics. He found the sulfonamide Prontosil to be effective against streptococcus, and treated his own daughter with it, saving her the amputation of an arm.
Domagk was appointed director of Bayer's Institute of Pathology and Bacteriology, where he continued the studies of Josef Klarer and Fritz Mietzsch, based on works by Paul Ehrlich, to use dyes, at that time a major product of IG Farben, as antibiotics. He found the sulfonamide Prontosil to be effective against streptococcus, and treated his own daughter with it, saving her the amputation of an arm.
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In 1939, Domagk received the Nobel Prize in Medicine for this discovery, the
In 1939, Domagk received the Nobel Prize in Medicine for this discovery, the
first drug effective against bacterial infections. He was forced by the Nazi regime to refuse the prize and was arrested by the Gestapo and detained for a week. (This was because the Nazi-critical Carl von Ossietzky had won the Nobel Peace Prize in 1935, which had angered the German government and resulted in German nationals not being permitted by law to accept the Nobel Prize.) In the same year, Domagk was also awarded the Cameron Prize for Therapeutics of the University of Edinburgh.
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contribution to medicine
Domagk earned a medical degree from the University of
contribution to medicine
Domagk earned a medical degree from the University of
Kiel in 1921. He briefly taught at the University of Greifswald (1924–25) before joining the faculty of the University of Münster. In 1927 he became director of the I.G. Farbenindustrie (Bayer) Laboratory for Experimental Pathology and Bacteriology in Elberfeld (now in Wuppertal). There, inspired by the ideas of Paul Ehrlich, he began testing newly developed dyes for their possible effects against various infections.
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He noticed the antibacterial action of one of the dyes against streptococcal infection
He noticed the antibacterial action of one of the dyes against streptococcal infection
in mice. The dye, Prontosil red, was then tried clinically against streptococcal infections in humans with great success. The active component of Prontosil turned out to be sulfanilamide, which became another important sulfa drug.
Unable to accept the Nobel award at the time because of Nazi German policy, Domagk later (1947) received the gold medal and diploma. He also was active in research on tuberculosis and cancer.
Unable to accept the Nobel award at the time because of Nazi German policy, Domagk later (1947) received the gold medal and diploma. He also was active in research on tuberculosis and cancer.