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- 2. Patient J. 1985 August 25, 2015 surgery - extensive node-clearing excision of a tumor of the
- 3. March 2016: There has been the progression of the process into the axillary lymph node on
- 4. July 2017: there is acceleration of the disease to the cervical lymph node on the right.
- 5. September 13,2017 CT - metastatic lesion of the lymph nodes of the mediastinum and perinephric fat
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Слайд 2
Patient J. 1985
August 25, 2015 surgery - extensive node-clearing excision of
Patient J. 1985
August 25, 2015 surgery - extensive node-clearing excision of
a tumor of the skin of the back with a reconstructive plastic component.
Pathology histological test No. 134569-74 of August 31, 2015 showed the nodular pigment melanoma from spindle-shaped and nevus-like cells without ulceration, 2 mm height Breslow, Clark invasion II level, against previous nevus, mitosis is 1 per mm2, severe lymphoid infiltration.
There is no tumor growth along the cut-off lines. Dynamic observation is recommended.
Pathology histological test No. 134569-74 of August 31, 2015 showed the nodular pigment melanoma from spindle-shaped and nevus-like cells without ulceration, 2 mm height Breslow, Clark invasion II level, against previous nevus, mitosis is 1 per mm2, severe lymphoid infiltration.
There is no tumor growth along the cut-off lines. Dynamic observation is recommended.
Слайд 3
March 2016: There has been the progression of the process into
March 2016: There has been the progression of the process into
the axillary lymph node on the right and on the left.
Surgery: axillary-subscapular lymphadenectomy on the right.
Axillary lymphadenectomy on the left. BRAF mutation was detected.
There was radiation therapy on the right and left axillary regions. The immunotherapy with Interferon alpha 3-5 million IU is recommended.
Patient J. received immunotherapy for 1 year.
Surgery: axillary-subscapular lymphadenectomy on the right.
Axillary lymphadenectomy on the left. BRAF mutation was detected.
There was radiation therapy on the right and left axillary regions. The immunotherapy with Interferon alpha 3-5 million IU is recommended.
Patient J. received immunotherapy for 1 year.
Слайд 4
July 2017: there is acceleration of the disease to the cervical
July 2017: there is acceleration of the disease to the cervical
lymph node on the right.
August 4, 2017 there was a surgery: right-side posterior-lateral cervical lymphatic dissection.
Immunotherapy with dose escalation up to 9 million IU is recommended.
August 4, 2017 there was a surgery: right-side posterior-lateral cervical lymphatic dissection.
Immunotherapy with dose escalation up to 9 million IU is recommended.
Слайд 5
September 13,2017 CT - metastatic lesion of the lymph nodes of
September 13,2017 CT - metastatic lesion of the lymph nodes of
the mediastinum and perinephric fat were found.
There were formation of an unclear etiology in the thyroid gland. No lesions of the brain substance were detected. Treatment with BRAF + MEK inhibitors is recommended. Since September 2017, she has been taking Dabrafenib in combination with Trametinib.
PET-CT was on November,29 2017. The information of active specific tissue at that moment of the study were not received. There are postoperative fibrotic changes in the axillary region from both sides.
Therapy with Dabrafenib and Trametinib is continuing.
There were formation of an unclear etiology in the thyroid gland. No lesions of the brain substance were detected. Treatment with BRAF + MEK inhibitors is recommended. Since September 2017, she has been taking Dabrafenib in combination with Trametinib.
PET-CT was on November,29 2017. The information of active specific tissue at that moment of the study were not received. There are postoperative fibrotic changes in the axillary region from both sides.
Therapy with Dabrafenib and Trametinib is continuing.
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